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A Genome-Wide Association Study of Neuroticism in a Population-Based Sample

Author

Listed:
  • Federico C F Calboli
  • Federica Tozzi
  • Nicholas W Galwey
  • Athos Antoniades
  • Vincent Mooser
  • Martin Preisig
  • Peter Vollenweider
  • Dawn Waterworth
  • Gerard Waeber
  • Michael R Johnson
  • Pierandrea Muglia
  • David J Balding

Abstract

Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire. After Quality Control, we analysed 430,000 autosomal SNPs together with an additional 1.2 million SNPs imputed with high quality from the Hap Map CEU samples. We found a very small effect of population stratification, corrected using one principal component, and some cryptic kinship that required no correction. NKAIN2 showed suggestive evidence of association with neuroticism as a main effect (p

Suggested Citation

  • Federico C F Calboli & Federica Tozzi & Nicholas W Galwey & Athos Antoniades & Vincent Mooser & Martin Preisig & Peter Vollenweider & Dawn Waterworth & Gerard Waeber & Michael R Johnson & Pierandrea M, 2010. "A Genome-Wide Association Study of Neuroticism in a Population-Based Sample," PLOS ONE, Public Library of Science, vol. 5(7), pages 1-7, July.
    • Handle: RePEc:plo:pone00:0011504
    DOI: 10.1371/journal.pone.0011504
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