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A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01

Author

Listed:
  • Bruce A C Cree
  • John D Rioux
  • Jacob L McCauley
  • Pierre-Antoine F D Gourraud
  • Philippe Goyette
  • Joseph McElroy
  • Philip De Jager
  • Adam Santaniello
  • Timothy J Vyse
  • Peter K Gregersen
  • Daniel Mirel
  • David A Hafler
  • Jonathan L Haines
  • Margaret A Pericak-Vance
  • Alastair Compston
  • Stephen J Sawcer
  • Jorge R Oksenberg
  • Stephen L Hauser
  • IMAGEN
  • IMSGC

Abstract

Background: In Northern European descended populations, genetic susceptibility for multiple sclerosis (MS) is associated with alleles of the human leukocyte antigen (HLA) Class II gene DRB1. Whether other major histocompatibility complex (MHC) genes contribute to MS susceptibility is controversial. Methodology/Principal Findings: A case control analysis was performed using 958 single nucleotide polymorphisms (SNPs) spanning the MHC assayed in two independent datasets. The discovery dataset consisted of 1,018 cases and 1,795 controls and the replication dataset was composed of 1,343 cases and 1,379 controls. The most significantly MS-associated SNP in the discovery dataset was rs3135391, a Class II SNP known to tag the HLA-DRB1*15:01 allele, the primary MS susceptibility allele in the MHC (O.R. = 3.04, p

Suggested Citation

  • Bruce A C Cree & John D Rioux & Jacob L McCauley & Pierre-Antoine F D Gourraud & Philippe Goyette & Joseph McElroy & Philip De Jager & Adam Santaniello & Timothy J Vyse & Peter K Gregersen & Daniel Mi, 2010. "A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01," PLOS ONE, Public Library of Science, vol. 5(6), pages 1-10, June.
    • Handle: RePEc:plo:pone00:0011296
    DOI: 10.1371/journal.pone.0011296
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