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Early Antiretroviral Therapy Reduces AIDS Progression/Death in Individuals with Acute Opportunistic Infections: A Multicenter Randomized Strategy Trial

Author

Listed:
  • Andrew R Zolopa
  • Janet Andersen
  • Lauren Komarow
  • Ian Sanne
  • Alejandro Sanchez
  • Evelyn Hogg
  • Carol Suckow
  • William Powderly
  • for the ACTG A5164 study team

Abstract

Background: Optimal timing of ART initiation for individuals presenting with AIDS-related OIs has not been defined. Methods and Findings: A5164 was a randomized strategy trial of “early ART” - given within 14 days of starting acute OI treatment versus “deferred ART” - given after acute OI treatment is completed. Randomization was stratified by presenting OI and entry CD4 count. The primary week 48 endpoint was 3-level ordered categorical variable: 1. Death/AIDS progression; 2. No progression with incomplete viral suppression (ie HIV viral load (VL) ≥50 copies/ml); 3. No progression with optimal viral suppression (ie HIV VL

Suggested Citation

  • Andrew R Zolopa & Janet Andersen & Lauren Komarow & Ian Sanne & Alejandro Sanchez & Evelyn Hogg & Carol Suckow & William Powderly & for the ACTG A5164 study team, 2009. "Early Antiretroviral Therapy Reduces AIDS Progression/Death in Individuals with Acute Opportunistic Infections: A Multicenter Randomized Strategy Trial," PLOS ONE, Public Library of Science, vol. 4(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0005575
    DOI: 10.1371/journal.pone.0005575
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