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Polymorphisms in the Estrogen Receptor 1 and Vitamin C and Matrix Metalloproteinase Gene Families Are Associated with Susceptibility to Lymphoma

Author

Listed:
  • Christine F Skibola
  • Paige M Bracci
  • Eran Halperin
  • Alexandra Nieters
  • Alan Hubbard
  • Randi A Paynter
  • Danica R Skibola
  • Luz Agana
  • Nikolaus Becker
  • Patrick Tressler
  • Matthew S Forrest
  • Sriram Sankararaman
  • Lucia Conde
  • Elizabeth A Holly
  • Martyn T Smith

Abstract

Background: Non-Hodgkin lymphoma (NHL) is the fifth most common cancer in the U.S. and few causes have been identified. Genetic association studies may help identify environmental risk factors and enhance our understanding of disease mechanisms. Methodology/Principal Findings: 768 coding and haplotype tagging SNPs in 146 genes were examined using Illumina GoldenGate technology in a large population-based case-control study of NHL in the San Francisco Bay Area (1,292 cases 1,375 controls are included here). Statistical analyses were restricted to HIV- participants of white non-Hispanic origin. Genes involved in steroidogenesis, immune function, cell signaling, sunlight exposure, xenobiotic metabolism/oxidative stress, energy balance, and uptake and metabolism of cholesterol, folate and vitamin C were investigated. Sixteen SNPs in eight pathways and nine haplotypes were associated with NHL after correction for multiple testing at the adjusted q

Suggested Citation

  • Christine F Skibola & Paige M Bracci & Eran Halperin & Alexandra Nieters & Alan Hubbard & Randi A Paynter & Danica R Skibola & Luz Agana & Nikolaus Becker & Patrick Tressler & Matthew S Forrest & Srir, 2008. "Polymorphisms in the Estrogen Receptor 1 and Vitamin C and Matrix Metalloproteinase Gene Families Are Associated with Susceptibility to Lymphoma," PLOS ONE, Public Library of Science, vol. 3(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0002816
    DOI: 10.1371/journal.pone.0002816
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