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The Tell-Tale Heart: Population-Based Surveillance Reveals an Association of Rofecoxib and Celecoxib with Myocardial Infarction

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  • John S Brownstein
  • Margarita Sordo
  • Isaac S Kohane
  • Kenneth D Mandl

Abstract

Background: COX-2 selective inhibitors are associated with myocardial infarction (MI). We sought to determine whether population health monitoring would have revealed the effect of COX-2 inhibitors on population-level patterns of MI. Methodology/Principal Findings: We conducted a retrospective study of inpatients at two Boston hospitals, from January 1997 to March 2006. There was a population-level rise in the rate of MI that reached 52.0 MI-related hospitalizations per 100,000 (a two standard deviation exceedence) in January of 2000, eight months after the introduction of rofecoxib and one year after celecoxib. The exceedence vanished within one month of the withdrawal of rofecoxib. Trends in inpatient stay due to MI were tightly coupled to the rise and fall of prescriptions of COX-2 inhibitors, with an 18.5% increase in inpatient stays for MI when both rofecoxib and celecoxib were on the market (P

Suggested Citation

  • John S Brownstein & Margarita Sordo & Isaac S Kohane & Kenneth D Mandl, 2007. "The Tell-Tale Heart: Population-Based Surveillance Reveals an Association of Rofecoxib and Celecoxib with Myocardial Infarction," PLOS ONE, Public Library of Science, vol. 2(9), pages 1-6, September.
    • Handle: RePEc:plo:pone00:0000840
    DOI: 10.1371/journal.pone.0000840
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