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A simplified, combined protocol versus standard treatment for acute malnutrition in children 6–59 months (ComPAS trial): A cluster-randomized controlled non-inferiority trial in Kenya and South Sudan

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  • Jeanette Bailey
  • Charles Opondo
  • Natasha Lelijveld
  • Bethany Marron
  • Pamela Onyo
  • Eunice N Musyoki
  • Susan W Adongo
  • Mark Manary
  • André Briend
  • Marko Kerac

Abstract

Background: Malnutrition underlies 3 million child deaths worldwide. Current treatments differentiate severe acute malnutrition (SAM) from moderate acute malnutrition (MAM) with different products and programs. This differentiation is complex and costly. The Combined Protocol for Acute Malnutrition Study (ComPAS) assessed the effectiveness of a simplified, unified SAM/MAM protocol for children aged 6–59 months. Eliminating the need for separate products and protocols could improve the impact of programs by treating children more easily and cost-effectively, reaching more children globally. Methods and findings: A cluster-randomized non-inferiority trial compared a combined protocol against standard care in Kenya and South Sudan. Randomization was stratified by country. Combined protocol clinics treated children using 2 sachets of ready-to-use therapeutic food (RUTF) per day for those with mid-upper arm circumference (MUAC)

Suggested Citation

  • Jeanette Bailey & Charles Opondo & Natasha Lelijveld & Bethany Marron & Pamela Onyo & Eunice N Musyoki & Susan W Adongo & Mark Manary & André Briend & Marko Kerac, 2020. "A simplified, combined protocol versus standard treatment for acute malnutrition in children 6–59 months (ComPAS trial): A cluster-randomized controlled non-inferiority trial in Kenya and South Sudan," PLOS Medicine, Public Library of Science, vol. 17(7), pages 1-22, July.
    • Handle: RePEc:plo:pmed00:1003192
    DOI: 10.1371/journal.pmed.1003192
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