IDEAS home Printed from https://ideas.repec.org/a/oup/biomet/v100y2013i2p301-317.html
   My bibliography  Save this article

A multiple comparison procedure for hypotheses with gatekeeping structure

Author

Listed:
  • Xiaolong Luo
  • Guang Chen
  • S. Peter Ouyang
  • Bruce W. Turnbull

Abstract

We develop gatekeeping procedures that focus on comparing multiple treatments with a control when there are multiple endpoints. Our procedures utilize estimated correlations among individual test statistics without parametric assumptions. We make comparisons with other gatekeeping procedures with respect to properties of the trade-off in statistical power between families of hypotheses. We introduce a reward function to facilitate these comparisons. We illustrate our methods by simulation and an analysis of data from a randomized, multi-armed clinical trial. Copyright 2013, Oxford University Press.

Suggested Citation

  • Xiaolong Luo & Guang Chen & S. Peter Ouyang & Bruce W. Turnbull, 2013. "A multiple comparison procedure for hypotheses with gatekeeping structure," Biometrika, Biometrika Trust, vol. 100(2), pages 301-317.
    • Handle: RePEc:oup:biomet:v:100:y:2013:i:2:p:301-317
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1093/biomet/ass083
    Download Restriction: Access to full text is restricted to subscribers.
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:oup:biomet:v:100:y:2013:i:2:p:301-317. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Oxford University Press (email available below). General contact details of provider: https://academic.oup.com/biomet .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.