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Natural killer cell therapies

Author

Listed:
  • Eric Vivier

    (Innate Pharma
    Aix Marseille Université, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy
    APHM, Hôpital de la Timone, Marseille-Immunopôle
    Paris-Saclay Cancer Cluster)

  • Lucas Rebuffet

    (Aix Marseille Université, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy)

  • Emilie Narni-Mancinelli

    (Aix Marseille Université, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy)

  • Stéphanie Cornen

    (Innate Pharma)

  • Rob Y. Igarashi

    (Sanofi Oncology Research)

  • Valeria R. Fantin

    (Sanofi Oncology Research)

Abstract

Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK cells is their ability to recognize a wide range of cells in distress, particularly tumour cells and cells infected with viruses. They combine both direct effector functions against their cellular targets and participate in the generation, shaping and maintenance of a multicellular immune response. As our understanding has deepened, several therapeutic strategies focused on NK cells have been conceived and are currently in various stages of development, from preclinical investigations to clinical trials. Here we explore in detail the complexity of NK cell biology in humans and highlight the role of these cells in cancer immunity. We also analyse the harnessing of NK cell immunity through immune checkpoint inhibitors, NK cell engagers, and infusions of preactivated or genetically modified, autologous or allogeneic NK cell products.

Suggested Citation

  • Eric Vivier & Lucas Rebuffet & Emilie Narni-Mancinelli & Stéphanie Cornen & Rob Y. Igarashi & Valeria R. Fantin, 2024. "Natural killer cell therapies," Nature, Nature, vol. 626(8000), pages 727-736, February.
    • Handle: RePEc:nat:nature:v:626:y:2024:i:8000:d:10.1038_s41586-023-06945-1
    DOI: 10.1038/s41586-023-06945-1
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