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Why and where an HIV cure is needed and how it might be achieved

Author

Listed:
  • Thumbi Ndung’u

    (Africa Health Research Institute
    University of KwaZulu-Natal
    Max Planck Institute for Infection Biology)

  • Joseph M. McCune

    (Bill & Melinda Gates Foundation)

  • Steven G. Deeks

    (University of California San Francisco)

Abstract

Despite considerable global investment, only 60% of people who live with HIV currently receive antiretroviral therapy. The sustainability of current programmes remains unknown and key incidence rates are declining only modestly. Given the complexities and expenses associated with lifelong medication, developing an effective curative intervention is now a global priority. Here we review why and where a cure is needed, and how it might be achieved. We argue for expanding these efforts from resource-rich regions to sub-Saharan Africa and elsewhere: for any intervention to have an effect, region-specific biological, therapeutic and implementation issues must be addressed.

Suggested Citation

  • Thumbi Ndung’u & Joseph M. McCune & Steven G. Deeks, 2019. "Why and where an HIV cure is needed and how it might be achieved," Nature, Nature, vol. 576(7787), pages 397-405, December.
    • Handle: RePEc:nat:nature:v:576:y:2019:i:7787:d:10.1038_s41586-019-1841-8
    DOI: 10.1038/s41586-019-1841-8
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    Cited by:

    1. Daniel B. Reeves & Christian Gaebler & Thiago Y. Oliveira & Michael J. Peluso & Joshua T. Schiffer & Lillian B. Cohn & Steven G. Deeks & Michel C. Nussenzweig, 2023. "Impact of misclassified defective proviruses on HIV reservoir measurements," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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