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c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

Author

Listed:
  • Mo Xu

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Maria Pokrovskii

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Yi Ding

    (University of Rochester Medical Center)

  • Ren Yi

    (Courant Institute of Mathematical Sciences, New York University)

  • Christy Au

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
    The Howard Hughes Medical Institute, New York University School of Medicine)

  • Oliver J. Harrison

    (Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH)

  • Carolina Galan

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine)

  • Yasmine Belkaid

    (Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH
    NIAID Microbiome Program, NIH)

  • Richard Bonneau

    (Courant Institute of Mathematical Sciences, New York University
    Center for Genomics and Systems Biology, New York University
    Center for Computational Biology, Flatiron Institute, Simons Foundation)

  • Dan R. Littman

    (Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
    The Howard Hughes Medical Institute, New York University School of Medicine)

Abstract

The transcription factor c-MAF is required for the generation of Helicobacter-specific regulatory T cells that selectively restrain pro-inflammatory TH17 cells; the absence of c-MAF in mouse regulatory T cells results in pathobiont-dependent inflammatory bowel disease.

Suggested Citation

  • Mo Xu & Maria Pokrovskii & Yi Ding & Ren Yi & Christy Au & Oliver J. Harrison & Carolina Galan & Yasmine Belkaid & Richard Bonneau & Dan R. Littman, 2018. "c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont," Nature, Nature, vol. 554(7692), pages 373-377, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7692:d:10.1038_nature25500
    DOI: 10.1038/nature25500
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    Cited by:

    1. Zhaoyun Ding & Ting Cai & Jupei Tang & Hanxiao Sun & Xinyi Qi & Yunpeng Zhang & Yan Ji & Liyun Yuan & Huidan Chang & Yanhui Ma & Hong Zhou & Li Li & Huiming Sheng & Ju Qiu, 2022. "Setd2 supports GATA3+ST2+ thymic-derived Treg cells and suppresses intestinal inflammation," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Lizhen Zhu & Geng Li & Zhixin Liang & Tuan Qi & Kui Deng & Jiancheng Yu & Yue Peng & Jusheng Zheng & Yan Song & Xing Chang, 2023. "Microbiota-assisted iron uptake promotes immune tolerance in the intestine," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Carl-Philipp Hackstein & Dana Costigan & Linnea Drexhage & Claire Pearson & Samuel Bullers & Nicholas Ilott & Hossain Delowar Akther & Yisu Gu & Michael E. B. FitzPatrick & Oliver J. Harrison & Lucy C, 2022. "A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Nguyen T. Van & Karen Zhang & Rachel M. Wigmore & Anne I. Kennedy & Carolina R. DaSilva & Jialing Huang & Manju Ambelil & Jose H. Villagomez & Gerald J. O’Connor & Randy S. Longman & Miao Cao & Adam E, 2023. "Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Channakeshava Sokke Umeshappa & Patricia Solé & Jun Yamanouchi & Saswat Mohapatra & Bas G. J. Surewaard & Josep Garnica & Santiswarup Singha & Debajyoti Mondal & Elena Cortés-Vicente & Charlotte D’Mel, 2022. "Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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