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Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep

Author

Listed:
  • Kai Liu

    (Johns Hopkins University School of Medicine)

  • Juhyun Kim

    (Johns Hopkins University School of Medicine)

  • Dong Won Kim

    (Johns Hopkins University School of Medicine)

  • Yi Stephanie Zhang

    (Johns Hopkins University School of Medicine)

  • Hechen Bao

    (University of North Carolina School of Medicine)

  • Myrto Denaxa

    (The Francis Crick Institute)

  • Szu-Aun Lim

    (University of North Carolina School of Medicine)

  • Eileen Kim

    (Johns Hopkins University)

  • Chang Liu

    (Johns Hopkins University School of Medicine)

  • Ian R. Wickersham

    (The McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Vassilis Pachnis

    (The Francis Crick Institute)

  • Samer Hattar

    (National Institute of Mental Health)

  • Juan Song

    (University of North Carolina School of Medicine)

  • Solange P. Brown

    (Johns Hopkins University School of Medicine)

  • Seth Blackshaw

    (Johns Hopkins University School of Medicine)

Abstract

GABAergic Lhx6+ neurons in the ventral zona incerta promote both rapid eye movement and non-rapid eye movement sleep and inhibit the activity of wake-promoting GABAergic and Hcrt+ neurons of the lateral hypothalamus.

Suggested Citation

  • Kai Liu & Juhyun Kim & Dong Won Kim & Yi Stephanie Zhang & Hechen Bao & Myrto Denaxa & Szu-Aun Lim & Eileen Kim & Chang Liu & Ian R. Wickersham & Vassilis Pachnis & Samer Hattar & Juan Song & Solange , 2017. "Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep," Nature, Nature, vol. 548(7669), pages 582-587, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7669:d:10.1038_nature23663
    DOI: 10.1038/nature23663
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    Citations

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    Cited by:

    1. Han Guo & Jian-Bo Jiang & Wei Xu & Mu-Tian Zhang & Hui Chen & Huan-Ying Shi & Lu Wang & Miao He & Michael Lazarus & Shan-Qun Li & Zhi-Li Huang & Wei-Min Qu, 2023. "Parasubthalamic calretinin neurons modulate wakefulness associated with exploration in male mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Jilin W J L Wang & Fabrizio Lombardi & Xiyun Zhang & Christelle Anaclet & Plamen Ch Ivanov, 2019. "Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture," PLOS Computational Biology, Public Library of Science, vol. 15(11), pages 1-35, November.
    3. Fernando M. C. V. Reis & Sandra Maesta-Pereira & Matthias Ollivier & Peter J. Schuette & Ekayana Sethi & Blake A. Miranda & Emily Iniguez & Meghmik Chakerian & Eric Vaughn & Megha Sehgal & Darren C. T, 2024. "Control of feeding by a bottom-up midbrain-subthalamic pathway," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Sasa Teng & Fenghua Zhen & Li Wang & Jose Canovas Schalchli & Jane Simko & Xinyue Chen & Hao Jin & Christopher D. Makinson & Yueqing Peng, 2022. "Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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