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Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

Author

Listed:
  • Devin Sok

    (The Scripps Research Institute
    IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative)

  • Khoa M. Le

    (The Scripps Research Institute
    IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative)

  • Melissa Vadnais

    (The Scripps Research Institute)

  • Karen L. Saye-Francisco

    (The Scripps Research Institute
    IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute)

  • Joseph G. Jardine

    (The Scripps Research Institute
    IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute)

  • Jonathan L. Torres

    (The Scripps Research Institute)

  • Zachary T. Berndsen

    (The Scripps Research Institute)

  • Leopold Kong

    (The Scripps Research Institute)

  • Robyn Stanfield

    (The Scripps Research Institute)

  • Jennifer Ruiz

    (The Scripps Research Institute
    IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative)

  • Alejandra Ramos

    (The Scripps Research Institute
    IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    International AIDS Vaccine Initiative)

  • Chi-Hui Liang

    (The Scripps Research Institute
    IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute)

  • Patricia L. Chen

    (College of Veterinary Medicine and Biomedical Sciences, Texas A&M University)

  • Michael F. Criscitiello

    (College of Veterinary Medicine and Biomedical Sciences, Texas A&M University)

  • Waithaka Mwangi

    (College of Veterinary Medical, Kansas State University)

  • Ian A. Wilson

    (IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    The Scripps Research Institute)

  • Andrew B. Ward

    (IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    The Scripps Research Institute)

  • Vaughn V. Smider

    (The Scripps Research Institute)

  • Dennis R. Burton

    (The Scripps Research Institute
    IAVI Neutralizing Antibody Center, The Scripps Research Institute
    Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute
    Ragon Institute of MGH, MIT, and Harvard)

Abstract

Immunization of cows with a recombinant HIV envelope protein leads to the rapid development of potent, broadly neutralizing antibodies against HIV.

Suggested Citation

  • Devin Sok & Khoa M. Le & Melissa Vadnais & Karen L. Saye-Francisco & Joseph G. Jardine & Jonathan L. Torres & Zachary T. Berndsen & Leopold Kong & Robyn Stanfield & Jennifer Ruiz & Alejandra Ramos & C, 2017. "Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows," Nature, Nature, vol. 548(7665), pages 108-111, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7665:d:10.1038_nature23301
    DOI: 10.1038/nature23301
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    Cited by:

    1. Hristo L. Svilenov & Julia Sacherl & Ulrike Protzer & Martin Zacharias & Johannes Buchner, 2021. "Mechanistic principles of an ultra-long bovine CDR reveal strategies for antibody design," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Ting-Ting Li & Tian Xia & Jia-Qi Wu & Hao Hong & Zhao-Lin Sun & Ming Wang & Fang-Rong Ding & Jing Wang & Shuai Jiang & Jin Li & Jie Pan & Guang Yang & Jian-Nan Feng & Yun-Ping Dai & Xue-Min Zhang & Ta, 2023. "De novo genome assembly depicts the immune genomic characteristics of cattle," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Aaron Gupta & Kevin S. Kao & Rachel Yamin & Deena A. Oren & Yehuda Goldgur & Jonathan Du & Pete Lollar & Eric J. Sundberg & Jeffrey V. Ravetch, 2023. "Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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