IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v546y2017i7659d10.1038_nature22821.html
   My bibliography  Save this article

Microglia-dependent synapse loss in type I interferon-mediated lupus

Author

Listed:
  • Allison R. Bialas

    (Program in Cellular and Molecular Medicine, Harvard Medical School)

  • Jessy Presumey

    (Program in Cellular and Molecular Medicine, Harvard Medical School)

  • Abhishek Das

    (Program in Cellular and Molecular Medicine, Harvard Medical School)

  • Cees E. van der Poel

    (Program in Cellular and Molecular Medicine, Harvard Medical School)

  • Peter H. Lapchak

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Luka Mesin

    (Laboratory for Lymphocyte Dynamics, The Rockefeller University)

  • Gabriel Victora

    (Laboratory for Lymphocyte Dynamics, The Rockefeller University)

  • George C. Tsokos

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Christian Mawrin

    (University of Magdeburg
    Center for Behavioral Brain Sciences (CBBS), Otto-von-Guericke-University Magdeburg)

  • Ronald Herbst

    (MedImmune LLC)

  • Michael C. Carroll

    (Program in Cellular and Molecular Medicine, Harvard Medical School)

Abstract

Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.

Suggested Citation

  • Allison R. Bialas & Jessy Presumey & Abhishek Das & Cees E. van der Poel & Peter H. Lapchak & Luka Mesin & Gabriel Victora & George C. Tsokos & Christian Mawrin & Ronald Herbst & Michael C. Carroll, 2017. "Microglia-dependent synapse loss in type I interferon-mediated lupus," Nature, Nature, vol. 546(7659), pages 539-543, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7659:d:10.1038_nature22821
    DOI: 10.1038/nature22821
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature22821
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature22821?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alessandra Tesser & Alessia Pin & Elisabetta Mencaroni & Virginia Gulino & Alberto Tommasini, 2021. "Vasculitis, Autoimmunity, and Cytokines: How the Immune System Can Harm the Brain," IJERPH, MDPI, vol. 18(11), pages 1-17, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:546:y:2017:i:7659:d:10.1038_nature22821. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.