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Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Author

Listed:
  • Joshua D. Ooi

    (Centre for Inflammatory Diseases, Monash Medical Centre)

  • Jan Petersen

    (Biomedicine Discovery Institute, Monash University
    Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University)

  • Yu H. Tan

    (Biomedicine Discovery Institute, Monash University)

  • Megan Huynh

    (Centre for Inflammatory Diseases, Monash Medical Centre)

  • Zoe J. Willett

    (Centre for Inflammatory Diseases, Monash Medical Centre)

  • Sri H. Ramarathinam

    (Biomedicine Discovery Institute, Monash University)

  • Peter J. Eggenhuizen

    (Centre for Inflammatory Diseases, Monash Medical Centre)

  • Khai L. Loh

    (Biomedicine Discovery Institute, Monash University)

  • Katherine A. Watson

    (The Peter Doherty Institute for Infection and Immunity, University of Melbourne
    Walter and Eliza Hall Institute of Medical Research)

  • Poh Y. Gan

    (Centre for Inflammatory Diseases, Monash Medical Centre)

  • Maliha A. Alikhan

    (Centre for Inflammatory Diseases, Monash Medical Centre)

  • Nadine L. Dudek

    (Biomedicine Discovery Institute, Monash University)

  • Andreas Handel

    (College of Public Health, University of Georgia)

  • Billy G. Hudson

    (Vanderbilt University Medical Center)

  • Lars Fugger

    (Oxford Centre for Neuroinflammation, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford)

  • David A. Power

    (Austin Health
    University of Melbourne)

  • Stephen G. Holt

    (University of Melbourne
    The Royal Melbourne Hospital)

  • P. Toby Coates

    (Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital)

  • Jon W. Gregersen

    (Viborg Regional Hospital)

  • Anthony W. Purcell

    (Biomedicine Discovery Institute, Monash University)

  • Stephen R. Holdsworth

    (Centre for Inflammatory Diseases, Monash Medical Centre
    Monash Health)

  • Nicole L. La Gruta

    (Biomedicine Discovery Institute, Monash University
    The Peter Doherty Institute for Infection and Immunity, University of Melbourne)

  • Hugh H. Reid

    (Biomedicine Discovery Institute, Monash University
    Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University)

  • Jamie Rossjohn

    (Biomedicine Discovery Institute, Monash University
    Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University
    Institute of Infection and Immunity, Cardiff University School of Medicine)

  • A. Richard Kitching

    (Centre for Inflammatory Diseases, Monash Medical Centre
    Monash Health
    NHMRC Centre for Personalised Immunology, Monash University
    Monash Health)

Abstract

The molecular mechanism of Goodpasture disease is modelled to mechanistically determine how a human leukocyte antigen (HLA) allele can exert its dominant protective effect in autoimmune disease.

Suggested Citation

  • Joshua D. Ooi & Jan Petersen & Yu H. Tan & Megan Huynh & Zoe J. Willett & Sri H. Ramarathinam & Peter J. Eggenhuizen & Khai L. Loh & Katherine A. Watson & Poh Y. Gan & Maliha A. Alikhan & Nadine L. Du, 2017. "Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells," Nature, Nature, vol. 545(7653), pages 243-247, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7653:d:10.1038_nature22329
    DOI: 10.1038/nature22329
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    Cited by:

    1. Christopher Szeto & Pirooz Zareie & Rushika C. Wirasinha & Justin B. Zhang & Andrea T. Nguyen & Alan Riboldi-Tunnicliffe & Nicole L. Gruta & Stephanie Gras & Stephen R. Daley, 2022. "Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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