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Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Author

Listed:
  • W. P. Vermeij

    (Erasmus University Medical Center Rotterdam)

  • M. E. T. Dollé

    (Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1)

  • E. Reiling

    (Erasmus University Medical Center Rotterdam
    Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1)

  • D. Jaarsma

    (Erasmus University Medical Center Rotterdam, PO Box 2040)

  • C. Payan-Gomez

    (Erasmus University Medical Center Rotterdam
    Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario)

  • C. R. Bombardieri

    (Erasmus University Medical Center Rotterdam)

  • H. Wu

    (Erasmus University Medical Center Rotterdam, PO Box 2040)

  • A. J. M. Roks

    (Erasmus University Medical Center Rotterdam, PO Box 2040)

  • S. M. Botter

    (Erasmus University Medical Center Rotterdam
    Laboratory for Orthopedic Research, Balgrist University Hospital, Forchstrasse 340)

  • B. C. van der Eerden

    (Erasmus University Medical Center Rotterdam, PO Box 2040)

  • S. A. Youssef

    (Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, PO Box 80125)

  • R. V. Kuiper

    (Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, PO Box 80125
    †Present address: Department of Laboratory Medicine, Karolinska Institute, SE 171, 77 Stockholm, Sweden.)

  • B. Nagarajah

    (Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1)

  • C. T. van Oostrom

    (Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1)

  • R. M. C. Brandt

    (Erasmus University Medical Center Rotterdam)

  • S. Barnhoorn

    (Erasmus University Medical Center Rotterdam)

  • S. Imholz

    (Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1)

  • J. L. A. Pennings

    (Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1)

  • A. de Bruin

    (Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, PO Box 80125
    University Medical Center Groningen, PO Box 30001)

  • Á. Gyenis

    (Erasmus University Medical Center Rotterdam)

  • J. Pothof

    (Erasmus University Medical Center Rotterdam)

  • J. Vijg

    (Albert Einstein College of Medicine)

  • H. van Steeg

    (Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1
    Leiden University Medical Center, PO Box 9600)

  • J. H. J. Hoeijmakers

    (Erasmus University Medical Center Rotterdam
    CECAD Forschungszentrum, Universität zu Köln, Joseph-Stelzmann-Straße 26)

Abstract

A restricted diet extends the lives and improves the health of mice with accelerated ageing due to an inability to repair DNA damage.

Suggested Citation

  • W. P. Vermeij & M. E. T. Dollé & E. Reiling & D. Jaarsma & C. Payan-Gomez & C. R. Bombardieri & H. Wu & A. J. M. Roks & S. M. Botter & B. C. van der Eerden & S. A. Youssef & R. V. Kuiper & B. Nagaraja, 2016. "Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice," Nature, Nature, vol. 537(7620), pages 427-431, September.
    • Handle: RePEc:nat:nature:v:537:y:2016:i:7620:d:10.1038_nature19329
    DOI: 10.1038/nature19329
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    Cited by:

    1. Ross J. Hill & Nazareno Bona & Job Smink & Hannah K. Webb & Alastair Crisp & Juan I. Garaycoechea & Gerry P. Crossan, 2024. "p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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