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Structure of mammalian respiratory complex I

Author

Listed:
  • Jiapeng Zhu

    (MRC Mitochondrial Biology Unit
    † Present address: Nanjing University of Chinese Medicine, Nanjing 210023, China.)

  • Kutti R. Vinothkumar

    (MRC Laboratory of Molecular Biology)

  • Judy Hirst

    (MRC Mitochondrial Biology Unit)

Abstract

Electron cryomicroscopy structures are provided for all core and supernumerary protein subunits of mammalian complex I, a 45-subunit enzyme that powers eukaryotic respiration.

Suggested Citation

  • Jiapeng Zhu & Kutti R. Vinothkumar & Judy Hirst, 2016. "Structure of mammalian respiratory complex I," Nature, Nature, vol. 536(7616), pages 354-358, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7616:d:10.1038_nature19095
    DOI: 10.1038/nature19095
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    Cited by:

    1. Enrique Balderas & David R. Eberhardt & Sandra Lee & John M. Pleinis & Salah Sommakia & Anthony M. Balynas & Xue Yin & Mitchell C. Parker & Colin T. Maguire & Scott Cho & Marta W. Szulik & Anna Bakhti, 2022. "Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Ralf Steinhilper & Gabriele Höff & Johann Heider & Bonnie J. Murphy, 2022. "Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Blanca Jiménez-Gómez & Patricia Ortega-Sáenz & Lin Gao & Patricia González-Rodríguez & Paula García-Flores & Navdeep Chandel & José López-Barneo, 2023. "Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Koki Mise & Jianyin Long & Daniel L. Galvan & Zengchun Ye & Guizhen Fan & Rajesh Sharma & Irina I. Serysheva & Travis I. Moore & Collene R. Jeter & M. Anna Zal & Motoo Araki & Jun Wada & Paul T. Schum, 2024. "NDUFS4 regulates cristae remodeling in diabetic kidney disease," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Injae Chung & John J. Wright & Hannah R. Bridges & Bozhidar S. Ivanov & Olivier Biner & Caroline S. Pereira & Guilherme M. Arantes & Judy Hirst, 2022. "Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    6. M. Tanvir Rahman & M. Kristian Koski & Joanna Panecka-Hofman & Werner Schmitz & Alexander J. Kastaniotis & Rebecca C. Wade & Rik K. Wierenga & J. Kalervo Hiltunen & Kaija J. Autio, 2023. "An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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