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Operation of a homeostatic sleep switch

Author

Listed:
  • Diogo Pimentel

    (Centre for Neural Circuits and Behaviour, University of Oxford)

  • Jeffrey M. Donlea

    (Centre for Neural Circuits and Behaviour, University of Oxford)

  • Clifford B. Talbot

    (Centre for Neural Circuits and Behaviour, University of Oxford)

  • Seoho M. Song

    (Centre for Neural Circuits and Behaviour, University of Oxford)

  • Alexander J. F. Thurston

    (Centre for Neural Circuits and Behaviour, University of Oxford)

  • Gero Miesenböck

    (Centre for Neural Circuits and Behaviour, University of Oxford)

Abstract

Sleep-promoting neurons in Drosophila are shown to switch between electrical activity and silence as a function of sleep need; the switch is operated by dopamine and involves the antagonistic regulation of two potassium channels.

Suggested Citation

  • Diogo Pimentel & Jeffrey M. Donlea & Clifford B. Talbot & Seoho M. Song & Alexander J. F. Thurston & Gero Miesenböck, 2016. "Operation of a homeostatic sleep switch," Nature, Nature, vol. 536(7616), pages 333-337, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7616:d:10.1038_nature19055
    DOI: 10.1038/nature19055
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    Cited by:

    1. Elizabeth B Brown & Kreesha D Shah & Richard Faville & Benjamin Kottler & Alex C Keene, 2020. "Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity," PLOS Genetics, Public Library of Science, vol. 16(3), pages 1-26, March.
    2. Zhengchang Lei & Kristin Henderson & Krystyna Keleman, 2022. "A neural circuit linking learning and sleep in Drosophila long-term memory," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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