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Nucleotide excision repair is impaired by binding of transcription factors to DNA

Author

Listed:
  • Radhakrishnan Sabarinathan

    (Research Program on Biomedical Informatics, IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra)

  • Loris Mularoni

    (Research Program on Biomedical Informatics, IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra)

  • Jordi Deu-Pons

    (Research Program on Biomedical Informatics, IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra)

  • Abel Gonzalez-Perez

    (Research Program on Biomedical Informatics, IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra)

  • Núria López-Bigas

    (Research Program on Biomedical Informatics, IMIM Hospital del Mar Medical Research Institute and Universitat Pompeu Fabra
    Institució Catalana de Recerca i Estudis Avançats (ICREA))

Abstract

An analysis of cancer genomic data reveals an increased rate of somatic mutations at active transcription factor binding sites located both within promoter regions and distal from genes; the increased mutation rate at these genomic regions can be explained by reduced accessibility of the protein-bound DNA to nucleotide excision repair machinery.

Suggested Citation

  • Radhakrishnan Sabarinathan & Loris Mularoni & Jordi Deu-Pons & Abel Gonzalez-Perez & Núria López-Bigas, 2016. "Nucleotide excision repair is impaired by binding of transcription factors to DNA," Nature, Nature, vol. 532(7598), pages 264-267, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7598:d:10.1038_nature17661
    DOI: 10.1038/nature17661
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    Cited by:

    1. Noah Dukler & Mehreen R. Mughal & Ritika Ramani & Yi-Fei Huang & Adam Siepel, 2022. "Extreme purifying selection against point mutations in the human genome," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Sebastian Carrasco Pro & Heather Hook & David Bray & Daniel Berenzy & Devlin Moyer & Meimei Yin & Adam Thomas Labadorf & Ryan Tewhey & Trevor Siggers & Juan Ignacio Fuxman Bass, 2023. "Widespread perturbation of ETS factor binding sites in cancer," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Kathiresan Selvam & Smitha Sivapragasam & Gregory M. K. Poon & John J. Wyrick, 2023. "Detecting recurrent passenger mutations in melanoma by targeted UV damage sequencing," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Michael Habig & Cecile Lorrain & Alice Feurtey & Jovan Komluski & Eva H. Stukenbrock, 2021. "Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    5. Kerryn Elliott & Vinod Kumar Singh & Martin Boström & Erik Larsson, 2023. "Base-resolution UV footprinting by sequencing reveals distinctive damage signatures for DNA-binding proteins," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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