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Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

Author

Listed:
  • François Gerbe

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle
    INSERM
    Université de Montpellier)

  • Emmanuelle Sidot

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle
    INSERM
    Université de Montpellier)

  • Danielle J. Smyth

    (Institute of Immunology and Infection Research, School of Biological Sciences and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh
    †Present address: Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK.)

  • Makoto Ohmoto

    (Monell Chemical Senses Center)

  • Ichiro Matsumoto

    (Monell Chemical Senses Center)

  • Valérie Dardalhon

    (Université de Montpellier
    Institut de Génétique Moléculaire de Montpellier, CNRS)

  • Pierre Cesses

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle
    INSERM
    Université de Montpellier)

  • Laure Garnier

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle
    INSERM
    Université de Montpellier)

  • Marie Pouzolles

    (Université de Montpellier
    Institut de Génétique Moléculaire de Montpellier, CNRS)

  • Bénédicte Brulin

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle
    INSERM
    Université de Montpellier)

  • Marco Bruschi

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle
    INSERM
    Université de Montpellier)

  • Yvonne Harcus

    (Institute of Immunology and Infection Research, School of Biological Sciences and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh)

  • Valérie S. Zimmermann

    (Université de Montpellier
    Institut de Génétique Moléculaire de Montpellier, CNRS)

  • Naomi Taylor

    (Université de Montpellier
    Institut de Génétique Moléculaire de Montpellier, CNRS)

  • Rick M. Maizels

    (Institute of Immunology and Infection Research, School of Biological Sciences and Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh
    †Present address: Wellcome Trust Centre for Molecular Parasitology, Institute for Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK.)

  • Philippe Jay

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle
    INSERM
    Université de Montpellier)

Abstract

Epithelial tuft cells secretion of IL-25 is shown to regulate type 2 epithelial responses to helminth parasite infection via an IL-13/IL-4Rα-dependent feedback loop.

Suggested Citation

  • François Gerbe & Emmanuelle Sidot & Danielle J. Smyth & Makoto Ohmoto & Ichiro Matsumoto & Valérie Dardalhon & Pierre Cesses & Laure Garnier & Marie Pouzolles & Bénédicte Brulin & Marco Bruschi & Yvon, 2016. "Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites," Nature, Nature, vol. 529(7585), pages 226-230, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7585:d:10.1038_nature16527
    DOI: 10.1038/nature16527
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    Citations

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    Cited by:

    1. Ryan N. O’Keefe & Annalisa L. E. Carli & David Baloyan & David Chisanga & Wei Shi & Shoukat Afshar-Sterle & Moritz F. Eissmann & Ashleigh R. Poh & Bhupinder Pal & Cyril Seillet & Richard M. Locksley &, 2023. "A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Min Zhao & Fei Shao & Dou Yu & Jiaqi Zhang & Zhen Liu & Jiangwen Ma & Pengyan Xia & Shuo Wang, 2022. "Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Xiwen Xiong & Chenyan Yang & Wei-Qi He & Jiahui Yu & Yue Xin & Xinge Zhang & Rong Huang & Honghui Ma & Shaofang Xu & Zun Li & Jie Ma & Lin Xu & Qunyi Wang & Kaiqun Ren & Xiaoli S. Wu & Christopher R. , 2022. "Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Ihab Ansari & Llorenç Solé-Boldo & Meshi Ridnik & Julian Gutekunst & Oliver Gilliam & Maria Korshko & Timur Liwinski & Birgit Jickeli & Noa Weinberg-Corem & Michal Shoshkes-Carmel & Eli Pikarsky & Era, 2023. "TET2 and TET3 loss disrupts small intestine differentiation and homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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