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Basomedial amygdala mediates top-down control of anxiety and fear

Author

Listed:
  • Avishek Adhikari

    (Stanford University
    CNC Program, Stanford University)

  • Talia N. Lerner

    (Stanford University
    CNC Program, Stanford University)

  • Joel Finkelstein

    (Stanford University)

  • Sally Pak

    (Stanford University)

  • Joshua H. Jennings

    (Stanford University
    CNC Program, Stanford University)

  • Thomas J. Davidson

    (Stanford University
    CNC Program, Stanford University)

  • Emily Ferenczi

    (Stanford University
    Neurosciences Program, Stanford University)

  • Lisa A. Gunaydin

    (Stanford University
    Neurosciences Program, Stanford University)

  • Julie J. Mirzabekov

    (Stanford University)

  • Li Ye

    (Stanford University
    CNC Program, Stanford University)

  • Sung-Yon Kim

    (Stanford University
    Neurosciences Program, Stanford University)

  • Anna Lei

    (Stanford University)

  • Karl Deisseroth

    (Stanford University
    CNC Program, Stanford University
    Neurosciences Program, Stanford University
    Stanford University)

Abstract

Activation of the ventral medial prefrontal cortex–basomedial amygdala pathway is shown to suppress anxiety and fear-related freezing in mice, thus identifying the basomedial amygdala (and not intercalated cells, as posited by earlier models) as a novel target of top-down control.

Suggested Citation

  • Avishek Adhikari & Talia N. Lerner & Joel Finkelstein & Sally Pak & Joshua H. Jennings & Thomas J. Davidson & Emily Ferenczi & Lisa A. Gunaydin & Julie J. Mirzabekov & Li Ye & Sung-Yon Kim & Anna Lei , 2015. "Basomedial amygdala mediates top-down control of anxiety and fear," Nature, Nature, vol. 527(7577), pages 179-185, November.
    • Handle: RePEc:nat:nature:v:527:y:2015:i:7577:d:10.1038_nature15698
    DOI: 10.1038/nature15698
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    Cited by:

    1. Carole Morel & Sarah E. Montgomery & Long Li & Romain Durand-de Cuttoli & Emily M. Teichman & Barbara Juarez & Nikos Tzavaras & Stacy M. Ku & Meghan E. Flanigan & Min Cai & Jessica J. Walsh & Scott J., 2022. "Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Robert N. Fetcho & Baila S. Hall & David J. Estrin & Alexander P. Walsh & Peter J. Schuette & Jesse Kaminsky & Ashna Singh & Jacob Roshgodal & Charlotte C. Bavley & Viraj Nadkarni & Susan Antigua & Th, 2023. "Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Bob Bramson & Sjoerd Meijer & Annelies Nuland & Ivan Toni & Karin Roelofs, 2023. "Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Nahoko Kuga & Ryota Nakayama & Shota Morikawa & Haruya Yagishita & Daichi Konno & Hiromi Shiozaki & Natsumi Honjoya & Yuji Ikegaya & Takuya Sasaki, 2023. "Hippocampal sharp wave ripples underlie stress susceptibility in male mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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