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Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Author

Listed:
  • Minoru Takasato

    (Murdoch Childrens Research Institute, The Royal Children's Hospital Melbourne
    Institute for Molecular Bioscience, The University of Queensland)

  • Pei X. Er

    (Murdoch Childrens Research Institute, The Royal Children's Hospital Melbourne)

  • Han S. Chiu

    (Institute for Molecular Bioscience, The University of Queensland)

  • Barbara Maier

    (Institute for Molecular Bioscience, The University of Queensland)

  • Gregory J. Baillie

    (Institute for Molecular Bioscience, The University of Queensland)

  • Charles Ferguson

    (Institute for Molecular Bioscience, The University of Queensland)

  • Robert G. Parton

    (Institute for Molecular Bioscience, The University of Queensland)

  • Ernst J. Wolvetang

    (Australian Institute for Bioengineering and Nanotechnology, The University of Queensland)

  • Matthias S. Roost

    (Leiden University Medical Center)

  • Susana M. Chuva de Sousa Lopes

    (Leiden University Medical Center)

  • Melissa H. Little

    (Murdoch Childrens Research Institute, The Royal Children's Hospital Melbourne
    Institute for Molecular Bioscience, The University of Queensland
    The University of Melbourne)

Abstract

The kidney arises from two types of progenitors; here, the signalling conditions that induce the production of collecting ducts and functional nephrons from human pluripotent stem cells are determined, and organoids that recapitulate the functional regionalization of the kidney are produced.

Suggested Citation

  • Minoru Takasato & Pei X. Er & Han S. Chiu & Barbara Maier & Gregory J. Baillie & Charles Ferguson & Robert G. Parton & Ernst J. Wolvetang & Matthias S. Roost & Susana M. Chuva de Sousa Lopes & Melissa, 2015. "Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis," Nature, Nature, vol. 526(7574), pages 564-568, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7574:d:10.1038_nature15695
    DOI: 10.1038/nature15695
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    Cited by:

    1. Jessica M. Vanslambrouck & Sean B. Wilson & Ker Sin Tan & Ella Groenewegen & Rajeev Rudraraju & Jessica Neil & Kynan T. Lawlor & Sophia Mah & Michelle Scurr & Sara E. Howden & Kanta Subbarao & Melissa, 2022. "Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    2. Sienna R. Li & Ramila E. Gulieva & Louisa Helms & Nelly M. Cruz & Thomas Vincent & Hongxia Fu & Jonathan Himmelfarb & Benjamin S. Freedman, 2022. "Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Betz, Ulrich A.K. & Arora, Loukik & Assal, Reem A. & Azevedo, Hatylas & Baldwin, Jeremy & Becker, Michael S. & Bostock, Stefan & Cheng, Vinton & Egle, Tobias & Ferrari, Nicola & Schneider-Futschik, El, 2023. "Game changers in science and technology - now and beyond," Technological Forecasting and Social Change, Elsevier, vol. 193(C).
    4. Eun Jung Kim & Caressa Chen & Rebecca Gologorsky & Ana Santandreu & Alonso Torres & Nathan Wright & Mark S. Goodin & Jarrett Moyer & Benjamin W. Chui & Charles Blaha & Paul Brakeman & Shant Vartanian , 2023. "Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    5. Naomi Pode-Shakked & Megan Slack & Nambirajan Sundaram & Ruth Schreiber & Kyle W. McCracken & Benjamin Dekel & Michael Helmrath & Raphael Kopan, 2023. "RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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