IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v526y2015i7573d10.1038_nature15817.html
   My bibliography  Save this article

Pharmacogenomics in the clinic

Author

Listed:
  • Mary V. Relling

    (St. Jude Children's Research Hospital)

  • William E. Evans

    (St. Jude Children's Research Hospital)

Abstract

After decades of discovery, inherited variations have been identified in approximately 20 genes that affect about 80 medications and are actionable in the clinic. And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Current efforts that focus on the processes required to appropriately act on pharmacogenomic variability in the clinic are moving away from discovery and towards implementation of an evidenced-based strategy for improving the use of medications, thereby providing a cornerstone for precision medicine.

Suggested Citation

  • Mary V. Relling & William E. Evans, 2015. "Pharmacogenomics in the clinic," Nature, Nature, vol. 526(7573), pages 343-350, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7573:d:10.1038_nature15817
    DOI: 10.1038/nature15817
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature15817
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature15817?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Degtiar, Irina, 2017. "A review of international coverage and pricing strategies for personalized medicine and orphan drugs," Health Policy, Elsevier, vol. 121(12), pages 1240-1248.
    2. Ya-Yen Yu & Shih-Ming Tsao & Wen-Ta Yang & Wei-Chang Huang & Ching-Hsiung Lin & Wei-Wen Chen & Shun-Fa Yang & Hui-Ling Chiou & Yi-Wen Huang, 2019. "Association of Drug Metabolic Enzyme Genetic Polymorphisms and Adverse Drug Reactions in Patients Receiving Rifapentine and Isoniazid Therapy for Latent Tuberculosis," IJERPH, MDPI, vol. 17(1), pages 1-9, December.
    3. M Dahmani Fathallah, 2017. "Genomics, Gene Editing and Biologics: The Bolsters of the New Medical Paradigm," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 6(4), pages 75-78, July.
    4. Ligia Traldi Macedo & Vinicius Eduardo Ferrari & Juliana Carron & Ericka Francislaine Dias Costa & Leisa Lopes-Aguiar & Gustavo Jacob Lourenço & Carmen Silvia Passos Lima, 2019. "Cost-minimization analysis of GSTP1c.313A>G genotyping for the prevention of cisplatin-induced nausea and vomiting: A Bayesian inference approach," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-13, March.
    5. Perry, Seth W & Allison, Stephen & Bastiampillai, Tarun & Wong, Ma-Li & Licinio, Julio & Sharfstein, Steven S. & Wilcox, Holly C., 2019. "Rising US Suicides: Achieving Health Equity," OSF Preprints m5q64, Center for Open Science.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:526:y:2015:i:7573:d:10.1038_nature15817. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.