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MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

Author

Listed:
  • Cheryl M. Koh

    (Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research))

  • Marco Bezzi

    (Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research)
    Yong Loo Lin School of Medicine, National University of Singapore)

  • Diana H. P. Low

    (Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research))

  • Wei Xia Ang

    (Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research))

  • Shun Xie Teo

    (Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research))

  • Florence P. H. Gay

    (Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research))

  • Muthafar Al-Haddawi

    (Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research))

  • Soo Yong Tan

    (Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research))

  • Motomi Osato

    (Cancer Science Institute of Singapore (CSI), National University of Singapore)

  • Arianna Sabò

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT))

  • Bruno Amati

    (Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT)
    European Institute of Oncology (IEO))

  • Keng Boon Wee

    (Institute of High Performance Computing (IHPC), A*STAR (Agency for Science, Technology and Research), Connexis
    Bioinformatics Institute (BII), A*STAR (Agency for Science, Technology and Research))

  • Ernesto Guccione

    (Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research)
    Yong Loo Lin School of Medicine, National University of Singapore
    Cancer Science Institute of Singapore (CSI), National University of Singapore)

Abstract

The critical effectors of MYC overexpression during lymphomagenesis in transgenic mice are defined.

Suggested Citation

  • Cheryl M. Koh & Marco Bezzi & Diana H. P. Low & Wei Xia Ang & Shun Xie Teo & Florence P. H. Gay & Muthafar Al-Haddawi & Soo Yong Tan & Motomi Osato & Arianna Sabò & Bruno Amati & Keng Boon Wee & Ernes, 2015. "MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis," Nature, Nature, vol. 523(7558), pages 96-100, July.
    • Handle: RePEc:nat:nature:v:523:y:2015:i:7558:d:10.1038_nature14351
    DOI: 10.1038/nature14351
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    Cited by:

    1. Tatiana Erazo & Chiara M. Evans & Daniel Zakheim & Karen L. Chu & Alice Yunsi Refermat & Zahra Asgari & Xuejing Yang & Mariana Silva Ferreira & Sanjoy Mehta & Marco Vincenzo Russo & Andrea Knezevic & , 2022. "TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Zachary A. Hing & Janek S. Walker & Ethan C. Whipp & Lindsey Brinton & Matthew Cannon & Pu Zhang & Steven Sher & Casey B. Cempre & Fiona Brown & Porsha L. Smith & Claudio Agostinelli & Stefano A. Pile, 2023. "Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. Anja Deutzmann & Delaney K. Sullivan & Renumathy Dhanasekaran & Wei Li & Xinyu Chen & Ling Tong & Wadie D. Mahauad-Fernandez & John Bell & Adriane Mosley & Angela N. Koehler & Yulin Li & Dean W. Felsh, 2024. "Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Adam E. Hall & Sebastian Öther-Gee Pohl & Patrizia Cammareri & Stuart Aitken & Nicholas T. Younger & Michela Raponi & Caroline V. Billard & Alfonso Bolado Carrancio & Aslihan Bastem & Paz Freile & Fio, 2022. "RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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