Author
Listed:
- Bianca J. Marlin
(Skirball Institute for Biomolecular Medicine, New York University School of Medicine
Neuroscience Institute, New York University School of Medicine
New York University School of Medicine
New York University School of Medicine)
- Mariela Mitre
(Skirball Institute for Biomolecular Medicine, New York University School of Medicine
Neuroscience Institute, New York University School of Medicine
New York University School of Medicine
New York University School of Medicine)
- James A. D’amour
(Skirball Institute for Biomolecular Medicine, New York University School of Medicine
Neuroscience Institute, New York University School of Medicine
New York University School of Medicine
New York University School of Medicine)
- Moses V. Chao
(Skirball Institute for Biomolecular Medicine, New York University School of Medicine
Neuroscience Institute, New York University School of Medicine
New York University School of Medicine
New York University School of Medicine)
- Robert C. Froemke
(Skirball Institute for Biomolecular Medicine, New York University School of Medicine
Neuroscience Institute, New York University School of Medicine
New York University School of Medicine
New York University School of Medicine)
Abstract
Oxytocin is important for social interactions and maternal behaviour. However, little is known about when, where and how oxytocin modulates neural circuits to improve social cognition. Here we show how oxytocin enables pup retrieval behaviour in female mice by enhancing auditory cortical pup call responses. Retrieval behaviour required the left but not right auditory cortex, was accelerated by oxytocin in the left auditory cortex, and oxytocin receptors were preferentially expressed in the left auditory cortex. Neural responses to pup calls were lateralized, with co-tuned and temporally precise excitatory and inhibitory responses in the left cortex of maternal but not pup-naive adults. Finally, pairing calls with oxytocin enhanced responses by balancing the magnitude and timing of inhibition with excitation. Our results describe fundamental synaptic mechanisms by which oxytocin increases the salience of acoustic social stimuli. Furthermore, oxytocin-induced plasticity provides a biological basis for lateralization of auditory cortical processing.
Suggested Citation
Bianca J. Marlin & Mariela Mitre & James A. D’amour & Moses V. Chao & Robert C. Froemke, 2015.
"Oxytocin enables maternal behaviour by balancing cortical inhibition,"
Nature, Nature, vol. 520(7548), pages 499-504, April.
Handle:
RePEc:nat:nature:v:520:y:2015:i:7548:d:10.1038_nature14402
DOI: 10.1038/nature14402
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Cited by:
- Nihaad Paraouty & Justin D. Yao & Léo Varnet & Chi-Ning Chou & SueYeon Chung & Dan H. Sanes, 2023.
"Sensory cortex plasticity supports auditory social learning,"
Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Allen P. F. Chen & Jeffrey M. Malgady & Lu Chen & Kaiyo W. Shi & Eileen Cheng & Joshua L. Plotkin & Shaoyu Ge & Qiaojie Xiong, 2022.
"Nigrostriatal dopamine pathway regulates auditory discrimination behavior,"
Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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