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mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

Author

Listed:
  • William J. Faller

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Thomas J. Jackson

    (Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK)

  • John R. P. Knight

    (Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK)

  • Rachel A. Ridgway

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Thomas Jamieson

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Saadia A. Karim

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Carolyn Jones

    (Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK)

  • Sorina Radulescu

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • David J. Huels

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Kevin B. Myant

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Kate M. Dudek

    (Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK)

  • Helen A. Casey

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Alessandro Scopelliti

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Julia B. Cordero

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Marcos Vidal

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

  • Mario Pende

    (Institut Necker-Enfants Malades, CS 61431, Paris, France Institut National de la Santé et de la Recherche Médicale, U1151, F-75014 Paris, France Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France)

  • Alexey G. Ryazanov

    (Rutgers The State University of New Jersey, Robert Wood Johnson Medical School)

  • Nahum Sonenberg

    (McGill University, Montreal, Québec H3A 1A3, Canada)

  • Oded Meyuhas

    (IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel)

  • Michael N. Hall

    (Biozentrum, University of Basel, CH-4056 Basel, Switzerland)

  • Martin Bushell

    (Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK)

  • Anne E. Willis

    (Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK)

  • Owen J. Sansom

    (Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK)

Abstract

The mTORC1 complex has been implicated in tumorigenesis owing partially to its ability to increase protein translation; now, mTORC1 activity in the mouse intestine is shown not to be required for normal homeostasis but to be necessary for the triggering of tumorigenesis by APC mutations, suggesting that it could be a good target for the prevention of colorectal cancer in high-risk patients.

Suggested Citation

  • William J. Faller & Thomas J. Jackson & John R. P. Knight & Rachel A. Ridgway & Thomas Jamieson & Saadia A. Karim & Carolyn Jones & Sorina Radulescu & David J. Huels & Kevin B. Myant & Kate M. Dudek &, 2015. "mTORC1-mediated translational elongation limits intestinal tumour initiation and growth," Nature, Nature, vol. 517(7535), pages 497-500, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7535:d:10.1038_nature13896
    DOI: 10.1038/nature13896
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    Cited by:

    1. Joana Silva & Ferhat Alkan & Sofia Ramalho & Goda Snieckute & Stefan Prekovic & Ana Krotenberg Garcia & Santiago Hernández-Pérez & Rob Kammen & Danielle Barnum & Liesbeth Hoekman & Maarten Altelaar & , 2022. "Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Eva C. Freckmann & Emma Sandilands & Erin Cumming & Matthew Neilson & Alvaro Román-Fernández & Konstantina Nikolatou & Marisa Nacke & Tamsin R. M. Lannagan & Ann Hedley & David Strachan & Mark Salji &, 2022. "Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging," Nature Communications, Nature, vol. 13(1), pages 1-21, December.

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