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Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

Author

Listed:
  • Charlie G. Buffie

    (Infectious Diseases Service, Memorial Sloan Kettering Cancer Center
    Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center)

  • Vanni Bucci

    (Computational Biology Program, Sloan-Kettering Institute
    University of Massachusetts Dartmouth)

  • Richard R. Stein

    (Computational Biology Program, Sloan-Kettering Institute)

  • Peter T. McKenney

    (Infectious Diseases Service, Memorial Sloan Kettering Cancer Center
    Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center)

  • Lilan Ling

    (Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center)

  • Asia Gobourne

    (Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center)

  • Daniel No

    (Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center)

  • Hui Liu

    (Donald B. and Catherine C. Marron Cancer Metabolism Center, Sloan-Kettering Institute)

  • Melissa Kinnebrew

    (Infectious Diseases Service, Memorial Sloan Kettering Cancer Center
    Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center)

  • Agnes Viale

    (Genomics Core Laboratory, Sloan-Kettering Institute)

  • Eric Littmann

    (Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center)

  • Marcel R. M. van den Brink

    (Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center
    Immunology Program, Sloan-Kettering Institute)

  • Robert R. Jenq

    (Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center)

  • Ying Taur

    (Infectious Diseases Service, Memorial Sloan Kettering Cancer Center
    Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center)

  • Chris Sander

    (Computational Biology Program, Sloan-Kettering Institute)

  • Justin R. Cross

    (Donald B. and Catherine C. Marron Cancer Metabolism Center, Sloan-Kettering Institute)

  • Nora C. Toussaint

    (Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center
    Computational Biology Program, Sloan-Kettering Institute)

  • Joao B. Xavier

    (Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center
    Computational Biology Program, Sloan-Kettering Institute)

  • Eric G. Pamer

    (Infectious Diseases Service, Memorial Sloan Kettering Cancer Center
    Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center
    Immunology Program, Sloan-Kettering Institute)

Abstract

A fraction of the intestinal microbiota as precise as a single bacterial species confers infection resistance by synthesizing Clostridium difficile-inhibiting metabolites from host-derived bile salts.

Suggested Citation

  • Charlie G. Buffie & Vanni Bucci & Richard R. Stein & Peter T. McKenney & Lilan Ling & Asia Gobourne & Daniel No & Hui Liu & Melissa Kinnebrew & Agnes Viale & Eric Littmann & Marcel R. M. van den Brink, 2015. "Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile," Nature, Nature, vol. 517(7533), pages 205-208, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7533:d:10.1038_nature13828
    DOI: 10.1038/nature13828
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    Cited by:

    1. Elsa Hansen & Jason Karslake & Robert J Woods & Andrew F Read & Kevin B Wood, 2020. "Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations," PLOS Biology, Public Library of Science, vol. 18(5), pages 1-20, May.
    2. Xu, Libai & Kong, Dehan & Wang, Lidan & Gu, Hong & Kenney, Toby & Xu, Ximing, 2023. "Proportional stochastic generalized Lotka–Volterra model with an application to learning microbial community structures," Applied Mathematics and Computation, Elsevier, vol. 448(C).
    3. Liat Shenhav & Ori Furman & Leah Briscoe & Mike Thompson & Justin D Silverman & Itzhak Mizrahi & Eran Halperin, 2019. "Modeling the temporal dynamics of the gut microbial community in adults and infants," PLOS Computational Biology, Public Library of Science, vol. 15(6), pages 1-21, June.
    4. Tyler A Joseph & Liat Shenhav & Joao B Xavier & Eran Halperin & Itsik Pe’er, 2020. "Compositional Lotka-Volterra describes microbial dynamics in the simplex," PLOS Computational Biology, Public Library of Science, vol. 16(5), pages 1-22, May.

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