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Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

Author

Listed:
  • Xianqin Zhang

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology)

  • Dusan Bogunovic

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
    Icahn School of Medicine at Mount Sinai)

  • Béatrice Payelle-Brogard

    (Institut Pasteur, Cytokine Signaling Unit, CNRS URA 1961, 75724 Paris, France)

  • Véronique Francois-Newton

    (Institut Pasteur, Cytokine Signaling Unit, CNRS URA 1961, 75724 Paris, France)

  • Scott D. Speer

    (Icahn School of Medicine at Mount Sinai
    Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
    Microbiology Training Area, Graduate School of Biomedical Sciences of Icahn School of Medicine at Mount Sinai)

  • Chao Yuan

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology)

  • Stefano Volpi

    (Children’s Hospital Boston
    Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genoa, Italy)

  • Zhi Li

    (Institut Pasteur, Cytokine Signaling Unit, CNRS URA 1961, 75724 Paris, France)

  • Ozden Sanal

    (Hacettepe University Children’s Hospital, 06100 Ankara, Turkey)

  • Davood Mansouri

    (Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, 4739 Teheran, Iran)

  • Ilhan Tezcan

    (Hacettepe University Children’s Hospital, 06100 Ankara, Turkey)

  • Gillian I. Rice

    (Manchester Academic Health Science Centre, University of Manchester, Genetic Medicine, Manchester, M13 9NT, UK)

  • Chunyuan Chen

    (Third Xiangya Hospital, Central South University, Changsha 410013, China)

  • Nahal Mansouri

    (Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, 4739 Teheran, Iran)

  • Seyed Alireza Mahdaviani

    (Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, 4739 Teheran, Iran)

  • Yuval Itan

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University)

  • Bertrand Boisson

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University)

  • Satoshi Okada

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University)

  • Lu Zeng

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology)

  • Xing Wang

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology)

  • Hui Jiang

    (BGI-Shenzhen)

  • Wenqiang Liu

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology)

  • Tiantian Han

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology)

  • Delin Liu

    (Sangzhi County People's Hospital)

  • Tao Ma

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology)

  • Bo Wang

    (Genetics Laboratory, Hubei Maternal and Child Health Hospital, Wuhan, Hubei 430070, China)

  • Mugen Liu

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology)

  • Jing-Yu Liu

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology)

  • Qing K. Wang

    (Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
    Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA)

  • Dilek Yalnizoglu

    (Hacettepe University Children’s Hospital, 06100 Ankara, Turkey)

  • Lilliana Radoshevich

    (Institut Pasteur, Bacteria-Cell Interactions Unit, 75724 Paris, France)

  • Gilles Uzé

    (CNRS UMR5235, Montpellier II University, Place Eugène Bataillon, 34095 Montpellier, France)

  • Philippe Gros

    (McGill University, Montreal, QC H3A 0G4, Canada)

  • Flore Rozenberg

    (Paris Descartes University, 75006 Paris, France)

  • Shen-Ying Zhang

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University)

  • Emmanuelle Jouanguy

    (Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France
    Paris Descartes University, Imagine Institute, 75015 Paris, France)

  • Jacinta Bustamante

    (Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France
    Paris Descartes University, Imagine Institute, 75015 Paris, France
    Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children, 75015 Paris, France)

  • Adolfo García-Sastre

    (Icahn School of Medicine at Mount Sinai
    Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Laurent Abel

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France
    Paris Descartes University, Imagine Institute, 75015 Paris, France)

  • Pierre Lebon

    (Paris Descartes University, 75006 Paris, France)

  • Luigi D. Notarangelo

    (Children’s Hospital Boston)

  • Yanick J. Crow

    (Manchester Academic Health Science Centre, University of Manchester, Genetic Medicine, Manchester, M13 9NT, UK
    Paris Descartes University, Imagine Institute, 75015 Paris, France
    INSERM UMR 1163, Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute, 75006 Paris, France)

  • Stéphanie Boisson-Dupuis

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France
    Paris Descartes University, Imagine Institute, 75015 Paris, France)

  • Jean-Laurent Casanova

    (St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France
    Paris Descartes University, Imagine Institute, 75015 Paris, France
    Howard Hughes Medical Institute)

  • Sandra Pellegrini

    (Institut Pasteur, Cytokine Signaling Unit, CNRS URA 1961, 75724 Paris, France)

Abstract

ISG15 deficiency in humans leads to a failure to maintain adequate levels of USP18, triggering an increase in type I interferon production and signalling, and promoting auto-inflammatory disease.

Suggested Citation

  • Xianqin Zhang & Dusan Bogunovic & Béatrice Payelle-Brogard & Véronique Francois-Newton & Scott D. Speer & Chao Yuan & Stefano Volpi & Zhi Li & Ozden Sanal & Davood Mansouri & Ilhan Tezcan & Gillian I., 2015. "Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation," Nature, Nature, vol. 517(7532), pages 89-93, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7532:d:10.1038_nature13801
    DOI: 10.1038/nature13801
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    Citations

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    Cited by:

    1. Iona Wallace & Kheewoong Baek & J. Rajan Prabu & Ronnald Vollrath & Susanne Gronau & Brenda A. Schulman & Kirby N. Swatek, 2023. "Insights into the ISG15 transfer cascade by the UBE1L activating enzyme," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Wei Liu & Xu Liao & Ziye Luo & Yi Yang & Mai Chan Lau & Yuling Jiao & Xingjie Shi & Weiwei Zhai & Hongkai Ji & Joe Yeong & Jin Liu, 2023. "Probabilistic embedding, clustering, and alignment for integrating spatial transcriptomics data with PRECAST," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Kei-ichiro Arimoto & Sayuri Miyauchi & Ty D. Troutman & Yue Zhang & Mengdan Liu & Samuel A. Stoner & Amanda G. Davis & Jun-Bao Fan & Yi-Jou Huang & Ming Yan & Christopher K. Glass & Dong-Er Zhang, 2023. "Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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