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A three-dimensional human neural cell culture model of Alzheimer’s disease

Author

Listed:
  • Se Hoon Choi

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Young Hye Kim

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
    Korea Basic Science Institute, Cheongju-si, Chungbuk 363-883, South Korea)

  • Matthias Hebisch

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School
    Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, 53127 Bonn, Germany)

  • Christopher Sliwinski

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Seungkyu Lee

    (FM Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Stem Cell Institute)

  • Carla D’Avanzo

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Hechao Chen

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Basavaraj Hooli

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Caroline Asselin

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Julien Muffat

    (The Whitehead Institute for Biomedical Research)

  • Justin B. Klee

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Can Zhang

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Brian J. Wainger

    (FM Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Stem Cell Institute)

  • Michael Peitz

    (Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, 53127 Bonn, Germany)

  • Dora M. Kovacs

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Clifford J. Woolf

    (FM Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Stem Cell Institute)

  • Steven L. Wagner

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Rudolph E. Tanzi

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

  • Doo Yeon Kim

    (Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School)

Abstract

Early-onset familial Alzheimer’s disease mutations induce both amyloid-β and tau pathologies in differentiated human neural stem cells in 3D cultures.

Suggested Citation

  • Se Hoon Choi & Young Hye Kim & Matthias Hebisch & Christopher Sliwinski & Seungkyu Lee & Carla D’Avanzo & Hechao Chen & Basavaraj Hooli & Caroline Asselin & Julien Muffat & Justin B. Klee & Can Zhang , 2014. "A three-dimensional human neural cell culture model of Alzheimer’s disease," Nature, Nature, vol. 515(7526), pages 274-278, November.
    • Handle: RePEc:nat:nature:v:515:y:2014:i:7526:d:10.1038_nature13800
    DOI: 10.1038/nature13800
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    Cited by:

    1. Elaine T. Lim & Yingleong Chan & Pepper Dawes & Xiaoge Guo & Serkan Erdin & Derek J. C. Tai & Songlei Liu & Julia M. Reichert & Mannix J. Burns & Ying Kai Chan & Jessica J. Chiang & Katharina Meyer & , 2022. "Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Inbal Maniv & Mahasen Sarji & Anwar Bdarneh & Alona Feldman & Roi Ankawa & Elle Koren & Inbar Magid-Gold & Noa Reis & Despina Soteriou & Shiran Salomon-Zimri & Tali Lavy & Ellina Kesselman & Naama Koi, 2023. "Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Patricia R. Pitrez & Luis M. Monteiro & Oliver Borgogno & Xavier Nissan & Jerome Mertens & Lino Ferreira, 2024. "Cellular reprogramming as a tool to model human aging in a dish," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Hannah Drew Rickner & Lulu Jiang & Rui Hong & Nicholas K. O’Neill & Chromewell A. Mojica & Benjamin J. Snyder & Lushuang Zhang & Dipan Shaw & Maria Medalla & Benjamin Wolozin & Christine S. Cheng, 2022. "Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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