IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v509y2014i7502d10.1038_nature13251.html
   My bibliography  Save this article

Piezo2 is required for Merkel-cell mechanotransduction

Author

Listed:
  • Seung-Hyun Woo

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

  • Sanjeev Ranade

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

  • Andy D. Weyer

    (Neurobiology, and Anatomy, Medical College of Wisconsin)

  • Adrienne E. Dubin

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

  • Yoshichika Baba

    (Columbia University)

  • Zhaozhu Qiu

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
    Genomics Institute of the Novartis Research Foundation)

  • Matt Petrus

    (Genomics Institute of the Novartis Research Foundation)

  • Takashi Miyamoto

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute
    Present address: Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA.)

  • Kritika Reddy

    (Genomics Institute of the Novartis Research Foundation)

  • Ellen A. Lumpkin

    (Columbia University)

  • Cheryl L. Stucky

    (Neurobiology, and Anatomy, Medical College of Wisconsin)

  • Ardem Patapoutian

    (Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, The Scripps Research Institute)

Abstract

A mouse study shows that non-neuronal epidermal Merkel cells aid fine-touch perception in the skin through their expression of the Piezo2 mechanosensitive cation channel which then actively tunes the response to touch in adjacent somatosensory neurons.

Suggested Citation

  • Seung-Hyun Woo & Sanjeev Ranade & Andy D. Weyer & Adrienne E. Dubin & Yoshichika Baba & Zhaozhu Qiu & Matt Petrus & Takashi Miyamoto & Kritika Reddy & Ellen A. Lumpkin & Cheryl L. Stucky & Ardem Patap, 2014. "Piezo2 is required for Merkel-cell mechanotransduction," Nature, Nature, vol. 509(7502), pages 622-626, May.
    • Handle: RePEc:nat:nature:v:509:y:2014:i:7502:d:10.1038_nature13251
    DOI: 10.1038/nature13251
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature13251
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature13251?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jonathan Madar & Namrata Tiwari & Cristina Smith & Divya Sharma & Shanwei Shen & Alsiddig Elmahdi & Liya Y. Qiao, 2023. "Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    3. Sijia Xu & Jie-Xiang Yu & Hongshuang Guo & Shu Tian & You Long & Jing Yang & Lei Zhang, 2023. "Force-induced ion generation in zwitterionic hydrogels for a sensitive silent-speech sensor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Luis O. Romero & Rebeca Caires & A. Kaitlyn Victor & Juanma Ramirez & Francisco J. Sierra-Valdez & Patrick Walsh & Vincent Truong & Jungsoo Lee & Ugo Mayor & Lawrence T. Reiter & Valeria Vásquez & Jul, 2023. "Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Julia Ojeda-Alonso & Laura Calvo-Enrique & Ricardo Paricio-Montesinos & Rakesh Kumar & Ming-Dong Zhang & James F. A. Poulet & Patrik Ernfors & Gary R. Lewin, 2024. "Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Gregory J Gerling & Lingtian Wan & Benjamin U Hoffman & Yuxiang Wang & Ellen A Lumpkin, 2018. "Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes," PLOS Computational Biology, Public Library of Science, vol. 14(6), pages 1-21, June.
    7. Jeong Han Lee & Maria C. Perez-Flores & Seojin Park & Hyo Jeong Kim & Yingying Chen & Mincheol Kang & Jennifer Kersigo & Jinsil Choi & Phung N. Thai & Ryan L. Woltz & Dolores Columba Perez-Flores & Gu, 2024. "The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:509:y:2014:i:7502:d:10.1038_nature13251. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.