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Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

Author

Listed:
  • Laila Ritsma

    (Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Saskia I. J. Ellenbroek

    (Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Anoek Zomer

    (Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Hugo J. Snippert

    (University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands)

  • Frederic J. de Sauvage

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Benjamin D. Simons

    (Cavendish Laboratory, J. J. Thomson Avenue, University of Cambridge, Cambridge CB3 0HE, UK
    The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    The Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK)

  • Hans Clevers

    (Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Jacco van Rheenen

    (Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands)

Abstract

Long-term in vivo imaging of Confetti-labelled Lgr5-expressing intestinal stem cells shows that a dynamically heterogeneous cell population is able to function long-term as an equipotent stem-cell pool.

Suggested Citation

  • Laila Ritsma & Saskia I. J. Ellenbroek & Anoek Zomer & Hugo J. Snippert & Frederic J. de Sauvage & Benjamin D. Simons & Hans Clevers & Jacco van Rheenen, 2014. "Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging," Nature, Nature, vol. 507(7492), pages 362-365, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7492:d:10.1038_nature12972
    DOI: 10.1038/nature12972
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    Cited by:

    1. Márton Demeter & Imre Derényi & Gergely J. Szöllősi, 2022. "Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Yael Korem & Pablo Szekely & Yuval Hart & Hila Sheftel & Jean Hausser & Avi Mayo & Michael E Rothenberg & Tomer Kalisky & Uri Alon, 2015. "Geometry of the Gene Expression Space of Individual Cells," PLOS Computational Biology, Public Library of Science, vol. 11(7), pages 1-27, July.
    3. Shamir Montazid & Sheila Bandyopadhyay & Daniel W. Hart & Nan Gao & Brian Johnson & Sri G. Thrumurthy & Dustin J. Penn & Bettina Wernisch & Mukesh Bansal & Philipp M. Altrock & Fabian Rost & Patrycja , 2023. "Adult stem cell activity in naked mole rats for long-term tissue maintenance," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Makoto Takeo & Koh-ei Toyoshima & Riho Fujimoto & Tomoyo Iga & Miki Takase & Miho Ogawa & Takashi Tsuji, 2023. "Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Chiao-Peng Hsu & Alfredo Sciortino & Yu Alice Trobe & Andreas R. Bausch, 2022. "Activity-induced polar patterns of filaments gliding on a sphere," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    6. Philip S. Robinson & Laura E. Thomas & Federico Abascal & Hyunchul Jung & Luke M. R. Harvey & Hannah D. West & Sigurgeir Olafsson & Bernard C. H. Lee & Tim H. H. Coorens & Henry Lee-Six & Laura Butlin, 2022. "Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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