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Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

Author

Listed:
  • Iñigo Olalde

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

  • Morten E. Allentoft

    (Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark)

  • Federico Sánchez-Quinto

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

  • Gabriel Santpere

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

  • Charleston W. K. Chiang

    (University of California)

  • Michael DeGiorgio

    (University of California
    Pennsylvania State University, 502 Wartik Laboratory, University Park)

  • Javier Prado-Martinez

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

  • Juan Antonio Rodríguez

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

  • Simon Rasmussen

    (Center for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark)

  • Javier Quilez

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

  • Oscar Ramírez

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

  • Urko M. Marigorta

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

  • Marcos Fernández-Callejo

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

  • María Encina Prada

    (I.E.S.O. 'Los Salados', Junta de Castilla y León, E-49600 Benavente, Spain)

  • Julio Manuel Vidal Encinas

    (Junta de Castilla y León, Servicio de Cultura de León, E-24071 León, Spain)

  • Rasmus Nielsen

    (Center for Theoretical Evolutionary Genomics, University of California)

  • Mihai G. Netea

    (Inflammation and Immunity, Radboud University Nijmegen Medical Centre, 6500 Nijmegen, The Netherlands)

  • John Novembre

    (University of Chicago)

  • Richard A. Sturm

    (Institute for Molecular Bioscience, Melanogenix Group, The University of Queensland)

  • Pardis Sabeti

    (Center for Systems Biology, Harvard University
    Broad Institute of the Massachusetts Institute of Technology and Harvard)

  • Tomàs Marquès-Bonet

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain)

  • Arcadi Navarro

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain
    Centre de Regulació Genòmica (CRG), Barcelona 08003, Catalonia, Spain
    National Institute for Bioinformatics (INB), Barcelona 08003, Catalonia, Spain)

  • Eske Willerslev

    (Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark)

  • Carles Lalueza-Fox

    (Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain)

Abstract

A complete pre-agricultural European human genome from a ∼7,000-year-old Mesolithic skeleton suggests the existence of a common genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic, and ancestral alleles in several skin pigmentation genes suggest that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times.

Suggested Citation

  • Iñigo Olalde & Morten E. Allentoft & Federico Sánchez-Quinto & Gabriel Santpere & Charleston W. K. Chiang & Michael DeGiorgio & Javier Prado-Martinez & Juan Antonio Rodríguez & Simon Rasmussen & Javie, 2014. "Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European," Nature, Nature, vol. 507(7491), pages 225-228, March.
    • Handle: RePEc:nat:nature:v:507:y:2014:i:7491:d:10.1038_nature12960
    DOI: 10.1038/nature12960
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    Cited by:

    1. Kenichi Aoki, 2020. "A three-population wave-of-advance model for the European early Neolithic," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-15, May.
    2. Daniel Gómez-Sánchez & Iñigo Olalde & Federica Pierini & Laura Matas-Lalueza & Elena Gigli & Martina Lari & Sergi Civit & Marina Lozano & Josep Maria Vergès & David Caramelli & Oscar Ramírez & Carles , 2014. "Mitochondrial DNA from El Mirador Cave (Atapuerca, Spain) Reveals the Heterogeneity of Chalcolithic Populations," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-8, August.

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