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Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

Author

Listed:
  • Dante Neculai

    (Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada)

  • Michael Schwake

    (Biochemisches Institut der Christian-Albrechts-Universität zu Kiel, Otto-Hahn-Platz 9, 24118 Kiel, Germany
    Biochemie III, Fakultät für Chemie, Universität Bielefeld, Universitätstrasse 25, 33615 Bielefeld, Germany)

  • Mani Ravichandran

    (Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

  • Friederike Zunke

    (Biochemisches Institut der Christian-Albrechts-Universität zu Kiel, Otto-Hahn-Platz 9, 24118 Kiel, Germany)

  • Richard F. Collins

    (Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada)

  • Judith Peters

    (Biochemisches Institut der Christian-Albrechts-Universität zu Kiel, Otto-Hahn-Platz 9, 24118 Kiel, Germany)

  • Mirela Neculai

    (Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

  • Jonathan Plumb

    (Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada)

  • Peter Loppnau

    (Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

  • Juan Carlos Pizarro

    (Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Tulane University)

  • Alma Seitova

    (Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

  • William S. Trimble

    (Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada
    University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada)

  • Paul Saftig

    (Biochemisches Institut der Christian-Albrechts-Universität zu Kiel, Otto-Hahn-Platz 9, 24118 Kiel, Germany)

  • Sergio Grinstein

    (Cell Biology Program, The Hospital for Sick Children, Toronto M5G 1X8, Canada
    University of Toronto, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada
    Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 209 Victoria Street, Toronto M5C 1N8, Canada)

  • Sirano Dhe-Paganon

    (Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Dana-Farber Cancer Institute)

Abstract

These results reveal the first high-resolution structural analysis of LIMP-2 and, by homology modelling, the structure of SR-BI and CD36, members of the CD36 superfamily of scavenger receptor proteins.

Suggested Citation

  • Dante Neculai & Michael Schwake & Mani Ravichandran & Friederike Zunke & Richard F. Collins & Judith Peters & Mirela Neculai & Jonathan Plumb & Peter Loppnau & Juan Carlos Pizarro & Alma Seitova & Wil, 2013. "Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36," Nature, Nature, vol. 504(7478), pages 172-176, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7478:d:10.1038_nature12684
    DOI: 10.1038/nature12684
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    Cited by:

    1. Mphatso Kalemera & Dilyana Mincheva & Joe Grove & Christopher J R Illingworth, 2019. "Building a mechanistic mathematical model of hepatitis C virus entry," PLOS Computational Biology, Public Library of Science, vol. 15(3), pages 1-26, March.

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