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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

Author

Listed:
  • Andrea Ablasser

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Jonathan L. Schmid-Burgk

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Inga Hemmerling

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Gabor L. Horvath

    (Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Tobias Schmidt

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Eicke Latz

    (Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany
    University of Massachusetts Medical School)

  • Veit Hornung

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

Abstract

The cytoplasmic DNA receptor cGAS catalyses the synthesis of the second messenger cGAMP, which in turn activates type I interferon via STING; this study shows that cGAMP is transmitted to neighbouring cells via gap junction channels and activates STING, thus inducing an antiviral state in these bystander cells independent of paracrine interferon signalling.

Suggested Citation

  • Andrea Ablasser & Jonathan L. Schmid-Burgk & Inga Hemmerling & Gabor L. Horvath & Tobias Schmidt & Eicke Latz & Veit Hornung, 2013. "Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP," Nature, Nature, vol. 503(7477), pages 530-534, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7477:d:10.1038_nature12640
    DOI: 10.1038/nature12640
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    Cited by:

    1. Tomalika R. Ullah & Matt D. Johansen & Katherine R. Balka & Rebecca L. Ambrose & Linden J. Gearing & James Roest & Julian P. Vivian & Sunil Sapkota & W. Samantha N. Jayasekara & Daniel S. Wenholz & Vi, 2023. "Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Xingxing Ren & Qiuyuan Liu & Peirong Zhou & Tingyue Zhou & Decai Wang & Qiao Mei & Richard A. Flavell & Zhanju Liu & Mingsong Li & Wen Pan & Shu Zhu, 2024. "DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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