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Temperature triggers immune evasion by Neisseria meningitidis

Author

Listed:
  • Edmund Loh

    (Sir William Dunn School of Pathology, University of Oxford, Sir Parks Road, Oxford OX1 3RE, UK)

  • Elisabeth Kugelberg

    (Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK)

  • Alexander Tracy

    (Sir William Dunn School of Pathology, University of Oxford, Sir Parks Road, Oxford OX1 3RE, UK)

  • Qian Zhang

    (Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK)

  • Bridget Gollan

    (Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK)

  • Helen Ewles

    (Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK)

  • Ronald Chalmers

    (School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2NR, UK)

  • Vladimir Pelicic

    (Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK)

  • Christoph M. Tang

    (Sir William Dunn School of Pathology, University of Oxford, Sir Parks Road, Oxford OX1 3RE, UK
    Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK)

Abstract

Three Neisseria meningitidis RNA thermosensors important for resistance against complement-mediated immune killing are identified, located in the 5′ untranslated regions of genes necessary for capsule biosynthesis, expression of factor H binding protein and sialyation of lipolysaccharide; increased temperature may act as a warning signal for the bacterium, prompting it to enhance mechanisms of immune evasion.

Suggested Citation

  • Edmund Loh & Elisabeth Kugelberg & Alexander Tracy & Qian Zhang & Bridget Gollan & Helen Ewles & Ronald Chalmers & Vladimir Pelicic & Christoph M. Tang, 2013. "Temperature triggers immune evasion by Neisseria meningitidis," Nature, Nature, vol. 502(7470), pages 237-240, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7470:d:10.1038_nature12616
    DOI: 10.1038/nature12616
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    Cited by:

    1. Ling Zhong & Menghan Zhang & Libing Sun & Yu Yang & Bo Wang & Haibing Yang & Qiang Shen & Yu Xia & Jiarui Cui & Hui Hang & Yi Ren & Bo Pang & Xiangyu Deng & Yahui Zhan & Heng Li & Zhemin Zhou, 2023. "Distributed genotyping and clustering of Neisseria strains reveal continual emergence of epidemic meningococcus over a century," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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