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Temporal patterning of Drosophila medulla neuroblasts controls neural fates

Author

Listed:
  • Xin Li

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

  • Ted Erclik

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

  • Claire Bertet

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

  • Zhenqing Chen

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

  • Roumen Voutev

    (Columbia University Medical Center, 701 West 168th Street, New York, New York 10032, USA)

  • Srinidhi Venkatesh

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

  • Javier Morante

    (New York University, 100 Washington Square East, New York, New York 10003, USA
    Present addresses: Instituto de Neurociencias, CSIC, Universidad Miguel Hernández, Avenida Santiago Ramón y Cajal s/n, 03550 San Juan de Alicante, Spain (J.M.); Bogazici University, Department of Molecular Biology and Genetics, Kuzey Park Binasi 316, 34342 Bebek, Istanbul, Turkey (A.C.).)

  • Arzu Celik

    (New York University, 100 Washington Square East, New York, New York 10003, USA
    Present addresses: Instituto de Neurociencias, CSIC, Universidad Miguel Hernández, Avenida Santiago Ramón y Cajal s/n, 03550 San Juan de Alicante, Spain (J.M.); Bogazici University, Department of Molecular Biology and Genetics, Kuzey Park Binasi 316, 34342 Bebek, Istanbul, Turkey (A.C.).)

  • Claude Desplan

    (New York University, 100 Washington Square East, New York, New York 10003, USA)

Abstract

In the Drosophila optic lobes, the medulla processes visual information coming from inner photoreceptors R7 and R8 and from lamina neurons. It contains approximately 40,000 neurons belonging to more than 70 different types. Here we describe how precise temporal patterning of neural progenitors generates these different neural types. Five transcription factors—Homothorax, Eyeless, Sloppy paired, Dichaete and Tailless—are sequentially expressed in a temporal cascade in each of the medulla neuroblasts as they age. Loss of Eyeless, Sloppy paired or Dichaete blocks further progression of the temporal sequence. We provide evidence that this temporal sequence in neuroblasts, together with Notch-dependent binary fate choice, controls the diversification of the neuronal progeny. Although a temporal sequence of transcription factors had been identified in Drosophila embryonic neuroblasts, our work illustrates the generality of this strategy, with different sequences of transcription factors being used in different contexts.

Suggested Citation

  • Xin Li & Ted Erclik & Claire Bertet & Zhenqing Chen & Roumen Voutev & Srinidhi Venkatesh & Javier Morante & Arzu Celik & Claude Desplan, 2013. "Temporal patterning of Drosophila medulla neuroblasts controls neural fates," Nature, Nature, vol. 498(7455), pages 456-462, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7455:d:10.1038_nature12319
    DOI: 10.1038/nature12319
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    Cited by:

    1. Hailun Zhu & Sihai Dave Zhao & Alokananda Ray & Yu Zhang & Xin Li, 2022. "A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Zachary T. Spencer & Victoria H. Ng & Hassina Benchabane & Ghalia Saad Siddiqui & Deepesh Duwadi & Ben Maines & Jamal M. Bryant & Anna Schwarzkopf & Kai Yuan & Sara N. Kassel & Anant Mishra & Ashley P, 2023. "The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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