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Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

Author

Listed:
  • Chin Yee Ho

    (Cornell University
    Brigham and Women’s Hospital/Harvard Medical School)

  • Diana E. Jaalouk

    (Brigham and Women’s Hospital/Harvard Medical School
    Present address: American University of Beirut, Department of Biology, Beirut 1107 2020, Lebanon.)

  • Maria K. Vartiainen

    (Institute of Biotechnology, University of Helsinki)

  • Jan Lammerding

    (Cornell University
    Brigham and Women’s Hospital/Harvard Medical School)

Abstract

Lamin and emerin mutations causing cardiomyopathies are associated with an impairment in actin dynamics, resulting in aberrant nuclear translocation and downstream signalling of the transcription factor MKL1, which is pivotal for cardiac development.

Suggested Citation

  • Chin Yee Ho & Diana E. Jaalouk & Maria K. Vartiainen & Jan Lammerding, 2013. "Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics," Nature, Nature, vol. 497(7450), pages 507-511, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7450:d:10.1038_nature12105
    DOI: 10.1038/nature12105
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    Cited by:

    1. Caroline Dour & Maria Chatzifrangkeskou & Coline Macquart & Maria M. Magiera & Cécile Peccate & Charlène Jouve & Laura Virtanen & Tiina Heliö & Katriina Aalto-Setälä & Silvia Crasto & Bruno Cadot & Dé, 2022. "Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Robin M. Skory & Adam A. Moverley & Goli Ardestani & Yanina Alvarez & Ana Domingo-Muelas & Oz Pomp & Blake Hernandez & Piotr Tetlak & Stephanie Bissiere & Claudio D. Stern & Denny Sakkas & Nicolas Pla, 2023. "The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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