IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v496y2013i7446d10.1038_nature12051.html
   My bibliography  Save this article

High-level semi-synthetic production of the potent antimalarial artemisinin

Author

Listed:
  • C. J. Paddon

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • P. J. Westfall

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • D. J. Pitera

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • K. Benjamin

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • K. Fisher

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • D. McPhee

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • M. D. Leavell

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • A. Tai

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • A. Main

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • D. Eng

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • D. R. Polichuk

    (National Research Council of Canada, 110 Gymnasium Place)

  • K. H. Teoh

    (National Research Council of Canada, 110 Gymnasium Place
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • D. W. Reed

    (National Research Council of Canada, 110 Gymnasium Place)

  • T. Treynor

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • J. Lenihan

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • H. Jiang

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • M. Fleck

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • S. Bajad

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • G. Dang

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • D. Dengrove

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • D. Diola

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • G. Dorin

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • K. W. Ellens

    (National Research Council of Canada, 110 Gymnasium Place
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • S. Fickes

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • J. Galazzo

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • S. P. Gaucher

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • T. Geistlinger

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • R. Henry

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • M. Hepp

    (National Research Council of Canada, 110 Gymnasium Place
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • T. Horning

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • T. Iqbal

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • L. Kizer

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • B. Lieu

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • D. Melis

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • N. Moss

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • R. Regentin

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • S. Secrest

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • H. Tsuruta

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • R. Vazquez

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • L. F. Westblade

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • L. Xu

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • M. Yu

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • Y. Zhang

    (National Research Council of Canada, 110 Gymnasium Place
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • L. Zhao

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • J. Lievense

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA
    Present addresses: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, Indiana 46268, USA (P.J.W.); Radiant Genomics, Inc., 2430 Fifth Street, Suite D, Berkeley, California 94710, USA (A.M.); Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Arkansas 72401, USA (K.H.T.); Solazyme, Inc., 225 Gateway Boulevard, South San Francisco, California 94080, USA (J. Lenihan); Sutro Biopharma Inc., 310 Utah Avenue, South San Francisco, California 94080, USA (S.B.); Abbvie, 1500 Seaport Boulevard, Redwood City, California 94063, USA (G. Dang); Horticultural Sciences Department, University of Florida, PO Box 110690, Gainesville, Florida 32611-0690, USA (K.W.E.); Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada (M.H.); Regentin Consulting, 25409 Modoc Court, Hayward, California 94542, USA (R.R.); AS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, The Chinese Academy of Science, Wuhan 430074, China (Y.Z.); Genomatica, Inc., 10520 Wateridge Circle, San Diego, California 92121, USA (J. Lievense).)

  • P. S. Covello

    (National Research Council of Canada, 110 Gymnasium Place)

  • J. D. Keasling

    (University of California
    University of California
    Lawrence Berkeley National Laboratory
    Joint BioEnergy Institute, 5885 Hollis Street)

  • K. K. Reiling

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • N. S. Renninger

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

  • J. D. Newman

    (Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, California 94608, USA)

Abstract

Saccharomyces cerevisiae is engineered to produce high concentrations of artemisinic acid, a precursor of the artemisinin used in combination therapies for malaria treatment; an efficient and practical chemical process to convert artemisinic acid to artemisinin is also developed.

Suggested Citation

  • C. J. Paddon & P. J. Westfall & D. J. Pitera & K. Benjamin & K. Fisher & D. McPhee & M. D. Leavell & A. Tai & A. Main & D. Eng & D. R. Polichuk & K. H. Teoh & D. W. Reed & T. Treynor & J. Lenihan & H., 2013. "High-level semi-synthetic production of the potent antimalarial artemisinin," Nature, Nature, vol. 496(7446), pages 528-532, April.
    • Handle: RePEc:nat:nature:v:496:y:2013:i:7446:d:10.1038_nature12051
    DOI: 10.1038/nature12051
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12051
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12051?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zhong Li & Lilan Zhang & Kangwei Xu & Yuanyuan Jiang & Jieke Du & Xingwang Zhang & Ling-Hong Meng & Qile Wu & Lei Du & Xiaoju Li & Yuechan Hu & Zhenzhen Xie & Xukai Jiang & Ya-Jie Tang & Ruibo Wu & Re, 2023. "Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Xixian Chen & Rehka T & Jérémy Esque & Congqiang Zhang & Sudha Shukal & Chin Chin Lim & Leonard Ong & Derek Smith & Isabelle André, 2022. "Total enzymatic synthesis of cis-α-irone from a simple carbon source," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Nikolaj Lervad Hansen & Louise Kjaerulff & Quinn Kalby Heck & Victor Forman & Dan Staerk & Birger Lindberg Møller & Johan Andersen-Ranberg, 2022. "Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Anna Zimmermann & Julian E. Prieto-Vivas & Charlotte Cautereels & Anton Gorkovskiy & Jan Steensels & Yves Peer & Kevin J. Verstrepen, 2023. "A Cas3-base editing tool for targetable in vivo mutagenesis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Yifeng Zhang & Jie Gao & Lin Ma & Lichan Tu & Tianyuan Hu & Xiaoyi Wu & Ping Su & Yujun Zhao & Yuan Liu & Dan Li & Jiawei Zhou & Yan Yin & Yuru Tong & Huan Zhao & Yun Lu & Jiadian Wang & Wei Gao & Luq, 2023. "Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Shuangjia Zheng & Tao Zeng & Chengtao Li & Binghong Chen & Connor W. Coley & Yuedong Yang & Ruibo Wu, 2022. "Deep learning driven biosynthetic pathways navigation for natural products with BioNavi-NP," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    7. Jack Chun-Ting Liu & Ricardo De La Peña & Christian Tocol & Elizabeth S. Sattely, 2024. "Reconstitution of early paclitaxel biosynthetic network," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    8. Leixia Chu & Xiaoxia Luo & Taoting Zhu & Yingying Cao & Lili Zhang & Zixin Deng & Jiangtao Gao, 2022. "Harnessing phosphonate antibiotics argolaphos biosynthesis enables a synthetic biology-based green synthesis of glyphosate," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    9. Shan Yang & Ruibing Chen & Xuan Cao & Guodong Wang & Yongjin J. Zhou, 2024. "De novo biosynthesis of the hops bioactive flavonoid xanthohumol in yeast," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    10. Quanli Liu & Yi Liu & Gang Li & Otto Savolainen & Yun Chen & Jens Nielsen, 2021. "De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    11. Jiadong Hu & Shi Qiu & Feiyan Wang & Qing Li & Chun-Lei Xiang & Peng Di & Ziding Wu & Rui Jiang & Jinxing Li & Zhen Zeng & Jing Wang & Xingxing Wang & Yuchen Zhang & Shiyuan Fang & Yuqi Qiao & Jie Din, 2023. "Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    12. Abigail E. Bryson & Emily R. Lanier & Kin H. Lau & John P. Hamilton & Brieanne Vaillancourt & Davis Mathieu & Alan E. Yocca & Garret P. Miller & Patrick P. Edger & C. Robin Buell & Björn Hamberger, 2023. "Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:496:y:2013:i:7446:d:10.1038_nature12051. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.