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NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

Author

Listed:
  • Yael Costa

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Junjun Ding

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

  • Thorold W. Theunissen

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Francesco Faiola

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

  • Timothy A. Hore

    (Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK)

  • Pavel V. Shliaha

    (Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Miguel Fidalgo

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

  • Arven Saunders

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

  • Moyra Lawrence

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Sabine Dietmann

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Satyabrata Das

    (and Program in Molecular and Cellular Biology, University of Iowa)

  • Dana N. Levasseur

    (and Program in Molecular and Cellular Biology, University of Iowa)

  • Zhe Li

    (Indiana University)

  • Mingjiang Xu

    (Indiana University)

  • Wolf Reik

    (Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK
    Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK)

  • José C. R. Silva

    (Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK)

  • Jianlong Wang

    (Black Family Stem Cell Institute, Graduate School of Biological Sciences, Mount Sinai School of Medicine)

Abstract

The authors show that the pluripotency factor NANOG interacts with TET1 and TET2 methylcytosine hydroxylases, and that the hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine enhances the efficiency of somatic cell reprogramming in a NANOG-dependent manner.

Suggested Citation

  • Yael Costa & Junjun Ding & Thorold W. Theunissen & Francesco Faiola & Timothy A. Hore & Pavel V. Shliaha & Miguel Fidalgo & Arven Saunders & Moyra Lawrence & Sabine Dietmann & Satyabrata Das & Dana N., 2013. "NANOG-dependent function of TET1 and TET2 in establishment of pluripotency," Nature, Nature, vol. 495(7441), pages 370-374, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7441:d:10.1038_nature11925
    DOI: 10.1038/nature11925
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    Cited by:

    1. Timothy D. Arthur & Jennifer P. Nguyen & Agnieszka D’Antonio-Chronowska & Hiroko Matsui & Nayara S. Silva & Isaac N. Joshua & André D. Luchessi & William W. Young Greenwald & Matteo D’Antonio & Martin, 2024. "Complex regulatory networks influence pluripotent cell state transitions in human iPSCs," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Javier Rodríguez-Ubreva & Anna Arutyunyan & Marc Jan Bonder & Lucía Del Pino-Molina & Stephen J. Clark & Carlos de la Calle-Fabregat & Luz Garcia-Alonso & Louis-François Handfield & Laura Ciudad & Edu, 2022. "Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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