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PRC1 coordinates timing of sexual differentiation of female primordial germ cells

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  • Shihori Yokobayashi

    (Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    Present address: Department of Reprogramming Science, Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin Yoshida, Sakyo-ku, Kyoto 606-8507, Japan.)

  • Ching-Yeu Liang

    (Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    Faculty of Sciences, University of Basel, CH-4056 Basel, Switzerland)

  • Hubertus Kohler

    (Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Peter Nestorov

    (Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    Faculty of Sciences, University of Basel, CH-4056 Basel, Switzerland)

  • Zichuan Liu

    (Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Miguel Vidal

    (Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), 28040 Madrid, Spain)

  • Maarten van Lohuizen

    (the Netherlands Cancer Institute (NKI), 1066 CX Amsterdam, the Netherlands)

  • Tim C. Roloff

    (Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Antoine H. F. M. Peters

    (Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058 Basel, Switzerland
    Faculty of Sciences, University of Basel, CH-4056 Basel, Switzerland)

Abstract

The Polycomb repressive complex 1 (PRC1) is found to have important gene-dosage-dependent and sex-specific roles in primordial germ cell (PGC) development, including the maintenance of high levels of Oct4 and Nanog and ensuring the proper timing of meiosis through the suppression of retinoic acid signalling in female PGCs.

Suggested Citation

  • Shihori Yokobayashi & Ching-Yeu Liang & Hubertus Kohler & Peter Nestorov & Zichuan Liu & Miguel Vidal & Maarten van Lohuizen & Tim C. Roloff & Antoine H. F. M. Peters, 2013. "PRC1 coordinates timing of sexual differentiation of female primordial germ cells," Nature, Nature, vol. 495(7440), pages 236-240, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7440:d:10.1038_nature11918
    DOI: 10.1038/nature11918
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    Cited by:

    1. Ryuki Shimada & Yuzuru Kato & Naoki Takeda & Sayoko Fujimura & Kei-ichiro Yasunaga & Shingo Usuki & Hitoshi Niwa & Kimi Araki & Kei-ichiro Ishiguro, 2023. "STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Mengwen Hu & Yu-Han Yeh & Yasuhisa Munakata & Hironori Abe & Akihiko Sakashita & So Maezawa & Miguel Vidal & Haruhiko Koseki & Neil Hunter & Richard M. Schultz & Satoshi H. Namekawa, 2022. "PRC1-mediated epigenetic programming is required to generate the ovarian reserve," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Kentaro Mochizuki & Jafar Sharif & Kenjiro Shirane & Kousuke Uranishi & Aaron B. Bogutz & Sanne M. Janssen & Ayumu Suzuki & Akihiko Okuda & Haruhiko Koseki & Matthew C. Lorincz, 2021. "Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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