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Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Author

Listed:
  • Ursula Fünfschilling

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Lotti M. Supplie

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Don Mahad

    (Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Present addresses: Center for Neuroregeneration, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK (D.M.); Department of Molecular Physiology, Institute of Physiology, University of Saarland, D-66421 Homburg, Germany (A.S.S.); Department of Neurosurgery, Charité-University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany (B.G.B.); Department of Diagnostic Radiology, Am Botanischen Garten 14, University of Kiel, D-24118 Kiel, Germany.)

  • Susann Boretius

    (Biomedizinische NMR Forschungs GmbH am Max Planck Institute of Biophysical Chemistry, D-37070 Göttingen, Germany)

  • Aiman S. Saab

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
    Present addresses: Center for Neuroregeneration, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK (D.M.); Department of Molecular Physiology, Institute of Physiology, University of Saarland, D-66421 Homburg, Germany (A.S.S.); Department of Neurosurgery, Charité-University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany (B.G.B.); Department of Diagnostic Radiology, Am Botanischen Garten 14, University of Kiel, D-24118 Kiel, Germany.)

  • Julia Edgar

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Bastian G. Brinkmann

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
    Present addresses: Center for Neuroregeneration, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK (D.M.); Department of Molecular Physiology, Institute of Physiology, University of Saarland, D-66421 Homburg, Germany (A.S.S.); Department of Neurosurgery, Charité-University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany (B.G.B.); Department of Diagnostic Radiology, Am Botanischen Garten 14, University of Kiel, D-24118 Kiel, Germany.)

  • Celia M. Kassmann

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Iva D. Tzvetanova

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Wiebke Möbius

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
    Present addresses: Center for Neuroregeneration, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK (D.M.); Department of Molecular Physiology, Institute of Physiology, University of Saarland, D-66421 Homburg, Germany (A.S.S.); Department of Neurosurgery, Charité-University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany (B.G.B.); Department of Diagnostic Radiology, Am Botanischen Garten 14, University of Kiel, D-24118 Kiel, Germany.)

  • Francisca Diaz

    (University of Miami, Miller School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA)

  • Dies Meijer

    (Erasmus MC, 3000 CA Rotterdam, Netherlands)

  • Ueli Suter

    (Institute of Cell Biology, ETH Hönggerberg, Schafmattstrasse 18, 8093 Zürich, Switzerland)

  • Bernd Hamprecht

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Michael W. Sereda

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
    University of Göttingen (UMG), Robert-Koch-Strasse 40, D-37075 Göttingen, Germany)

  • Carlos T. Moraes

    (University of Miami, Miller School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA)

  • Jens Frahm

    (Biomedizinische NMR Forschungs GmbH am Max Planck Institute of Biophysical Chemistry, D-37070 Göttingen, Germany)

  • Sandra Goebbels

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Klaus-Armin Nave

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

Abstract

After myelination, oligodendrocytes are able to survive without mitochondrial respiration, suggesting that they can switch to aerobic glycolysis and release lactate.

Suggested Citation

  • Ursula Fünfschilling & Lotti M. Supplie & Don Mahad & Susann Boretius & Aiman S. Saab & Julia Edgar & Bastian G. Brinkmann & Celia M. Kassmann & Iva D. Tzvetanova & Wiebke Möbius & Francisca Diaz & Di, 2012. "Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity," Nature, Nature, vol. 485(7399), pages 517-521, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7399:d:10.1038_nature11007
    DOI: 10.1038/nature11007
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    Cited by:

    1. Kunkun Zhang & Shaoxuan Chen & Qihua Yang & Shuanghui Guo & Qiang Chen & Zhixiong Liu & Li Li & Mengyun Jiang & Hongda Li & Jin Hu & Xu Pan & Wenbo Deng & Naian Xiao & Bo Wang & Zhan-xiang Wang & Lian, 2022. "The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Xiao-Ru Ma & Xudong Zhu & Yujie Xiao & Hui-Min Gu & Shuang-Shuang Zheng & Liang Li & Fan Wang & Zhao-Jun Dong & Di-Xian Wang & Yang Wu & Chenyu Yang & Wenhong Jiang & Ke Yao & Yue Yin & Yang Zhang & C, 2022. "Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Siyi He & Yue Zhao & Yongsheng Fan & Xue Zhao & Jun Yu & Jie Xie & Chunhong Wang & Jianmei Su, 2019. "Research Trends and Hotspots Analysis Related to Monocarboxylate Transporter 1: A Study Based on Bibliometric Analysis," IJERPH, MDPI, vol. 16(7), pages 1-15, March.

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