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A new understanding of the decoding principle on the ribosome

Author

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  • Natalia Demeshkina

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France; CNRS, UMR7104, Illkirch 67400, France; INSERM, U964, Illkirch 67400, France; Université de Strasbourg
    CNRS, UMR7104, Illkirch 67400, France)

  • Lasse Jenner

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France; CNRS, UMR7104, Illkirch 67400, France; INSERM, U964, Illkirch 67400, France; Université de Strasbourg
    CNRS, UMR7104, Illkirch 67400, France)

  • Eric Westhof

    (Architecture et Réactivité de l’ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg 67084, France)

  • Marat Yusupov

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France; CNRS, UMR7104, Illkirch 67400, France; INSERM, U964, Illkirch 67400, France; Université de Strasbourg
    CNRS, UMR7104, Illkirch 67400, France)

  • Gulnara Yusupova

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch 67400, France; CNRS, UMR7104, Illkirch 67400, France; INSERM, U964, Illkirch 67400, France; Université de Strasbourg
    CNRS, UMR7104, Illkirch 67400, France)

Abstract

An integrated mechanism for decoding is proposed, based on six X-ray structures of the 70S ribosome determined at 3.1–3.4 Å resolution, modelling cognate or near-cognate states of the decoding centre at the proofreading step.

Suggested Citation

  • Natalia Demeshkina & Lasse Jenner & Eric Westhof & Marat Yusupov & Gulnara Yusupova, 2012. "A new understanding of the decoding principle on the ribosome," Nature, Nature, vol. 484(7393), pages 256-259, April.
    • Handle: RePEc:nat:nature:v:484:y:2012:i:7393:d:10.1038_nature10913
    DOI: 10.1038/nature10913
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    Cited by:

    1. Juntaek Oh & Zelin Shan & Shuichi Hoshika & Jun Xu & Jenny Chong & Steven A. Benner & Dmitry Lyumkis & Dong Wang, 2023. "A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Christine E. Carbone & Anna B. Loveland & Howard B. Gamper & Ya-Ming Hou & Gabriel Demo & Andrei A. Korostelev, 2021. "Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Sakshi Jain & Lukasz Koziej & Panagiotis Poulis & Igor Kaczmarczyk & Monika Gaik & Michal Rawski & Namit Ranjan & Sebastian Glatt & Marina V. Rodnina, 2023. "Modulation of translational decoding by m6A modification of mRNA," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Dylan Girodat & Hans-Joachim Wieden & Scott C. Blanchard & Karissa Y. Sanbonmatsu, 2023. "Geometric alignment of aminoacyl-tRNA relative to catalytic centers of the ribosome underpins accurate mRNA decoding," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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