IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v483y2012i7387d10.1038_nature10835.html
   My bibliography  Save this article

Gain control by layer six in cortical circuits of vision

Author

Listed:
  • Shawn R. Olsen

    (Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, University of California San Diego)

  • Dante S. Bortone

    (Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, University of California San Diego)

  • Hillel Adesnik

    (Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, University of California San Diego)

  • Massimo Scanziani

    (Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, University of California San Diego)

Abstract

After entering the cerebral cortex, sensory information spreads through six different horizontal neuronal layers that are interconnected by vertical axonal projections. It is believed that through these projections layers can influence each other's response to sensory stimuli, but the specific role that each layer has in cortical processing is still poorly understood. Here we show that layer six in the primary visual cortex of the mouse has a crucial role in controlling the gain of visually evoked activity in neurons of the upper layers without changing their tuning to orientation. This gain modulation results from the coordinated action of layer six intracortical projections to superficial layers and deep projections to the thalamus, with a substantial role of the intracortical circuit. This study establishes layer six as a major mediator of cortical gain modulation and suggests that it could be a node through which convergent inputs from several brain areas can regulate the earliest steps of cortical visual processing.

Suggested Citation

  • Shawn R. Olsen & Dante S. Bortone & Hillel Adesnik & Massimo Scanziani, 2012. "Gain control by layer six in cortical circuits of vision," Nature, Nature, vol. 483(7387), pages 47-52, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10835
    DOI: 10.1038/nature10835
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10835
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10835?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yanjie Wang & Zhaonan Chen & Guofen Ma & Lizhao Wang & Yanmei Liu & Meiling Qin & Xiang Fei & Yifan Wu & Min Xu & Siyu Zhang, 2023. "A frontal transcallosal inhibition loop mediates interhemispheric balance in visuospatial processing," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Katharina Ziegler & Ross Folkard & Antonio J. Gonzalez & Jan Burghardt & Sailaja Antharvedi-Goda & Jesus Martin-Cortecero & Emilio Isaías-Camacho & Sanjeev Kaushalya & Linette Liqi Tan & Thomas Kuner , 2023. "Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Elaida D. Dimwamwa & Aurélie Pala & Vivek Chundru & Nathaniel C. Wright & Garrett B. Stanley, 2024. "Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Koun Onodera & Hiroyuki K. Kato, 2022. "Translaminar recurrence from layer 5 suppresses superficial cortical layers," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Milad Hobbi Mobarhan & Geir Halnes & Pablo Martínez-Cañada & Torkel Hafting & Marianne Fyhn & Gaute T Einevoll, 2018. "Firing-rate based network modeling of the dLGN circuit: Effects of cortical feedback on spatiotemporal response properties of relay cells," PLOS Computational Biology, Public Library of Science, vol. 14(5), pages 1-38, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10835. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.