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Inflammasomes in health and disease

Author

Listed:
  • Till Strowig

    (Yale University)

  • Jorge Henao-Mejia

    (Yale University)

  • Eran Elinav

    (Yale University)

  • Richard Flavell

    (Yale University
    Howard Hughes Medical Institute)

Abstract

Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage signals by inflammasomes results in direct activation of caspase-1, which subsequently induces secretion of potent pro-inflammatory cytokines and a form of cell death called pyroptosis. Inflammasome-mediated processes are important during microbial infections and also in regulating both metabolic processes and mucosal immune responses. We review the functions of the different inflammasome complexes and discuss how aberrations in them are implicated in the pathogenesis of human diseases.

Suggested Citation

  • Till Strowig & Jorge Henao-Mejia & Eran Elinav & Richard Flavell, 2012. "Inflammasomes in health and disease," Nature, Nature, vol. 481(7381), pages 278-286, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7381:d:10.1038_nature10759
    DOI: 10.1038/nature10759
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    Cited by:

    1. Shin-ichi Hirano & Yusuke Ichikawa & Bunpei Sato & Fumitake Satoh & Yoshiyasu Takefuji, 2020. "Hydrogen Is Promising for Medical Applications," Clean Technol., MDPI, vol. 2(4), pages 1-13, December.
    2. Demetrios Petrakis & Loukia Vassilopoulou & Charalampos Mamoulakis & Christos Psycharakis & Aliki Anifantaki & Stavros Sifakis & Anca Oana Docea & John Tsiaoussis & Antonios Makrigiannakis & Aristides, 2017. "Endocrine Disruptors Leading to Obesity and Related Diseases," IJERPH, MDPI, vol. 14(10), pages 1-18, October.
    3. Wendy N. Phoswa & Olive P. Khaliq & Simeon Eche, 2023. "A Review on Inflammasomes and Immune Checkpoints in Pre-Eclampsia Complicated with Tuberculosis and Human Immune Deficiency Virus," IJERPH, MDPI, vol. 20(17), pages 1-15, August.

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