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Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Author

Listed:
  • Caryn S. Ross-Innes

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Rory Stark

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Andrew E. Teschendorff

    (UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK)

  • Kelly A. Holmes

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • H. Raza Ali

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK)

  • Mark J. Dunning

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Gordon D. Brown

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Ondrej Gojis

    (Imperial College London, Hammersmith Campus, London W12 0NN, UK
    Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic
    Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic)

  • Ian O. Ellis

    (Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK)

  • Andrew R. Green

    (Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham NG5 1PB, UK)

  • Simak Ali

    (Imperial College London, Hammersmith Campus, London W12 0NN, UK)

  • Suet-Feung Chin

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK)

  • Carlo Palmieri

    (Imperial College London, Hammersmith Campus, London W12 0NN, UK)

  • Carlos Caldas

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge CB2 0XZ
    Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK
    Cambridge Experimental Cancer Medicine Centre (ECMC), Cambridge CB2 0RE, UK)

  • Jason S. Carroll

    (Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    University of Cambridge CB2 0XZ)

Abstract

Genome-wide mapping of oestrogen receptor-α binding sites in primary breast cancer tissues shows that oestrogen receptor binding is dynamically regulated and that the expression of genes near differentially bound regulatory regions is associated with clinical outcome.

Suggested Citation

  • Caryn S. Ross-Innes & Rory Stark & Andrew E. Teschendorff & Kelly A. Holmes & H. Raza Ali & Mark J. Dunning & Gordon D. Brown & Ondrej Gojis & Ian O. Ellis & Andrew R. Green & Simak Ali & Suet-Feung C, 2012. "Differential oestrogen receptor binding is associated with clinical outcome in breast cancer," Nature, Nature, vol. 481(7381), pages 389-393, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7381:d:10.1038_nature10730
    DOI: 10.1038/nature10730
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