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Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

Author

Listed:
  • Mardo Kõivomägi

    (Institute of Technology, University of Tartu)

  • Ervin Valk

    (Institute of Technology, University of Tartu)

  • Rainis Venta

    (Institute of Technology, University of Tartu)

  • Anna Iofik

    (Institute of Technology, University of Tartu)

  • Martin Lepiku

    (Institute of Technology, University of Tartu)

  • Eva Rose M. Balog

    (University of California)

  • Seth M. Rubin

    (University of California)

  • David O. Morgan

    (University of California)

  • Mart Loog

    (Institute of Technology, University of Tartu)

Abstract

Proteins as complex switches Multisite phosphorylation of a protein can allow an ultra-sensitive switch-like response. For example, in the yeast cyclin-dependent kinase (Cdk) inhibitor Sic1, it can lead to its rapid destruction and the initiation of S-phase of the cell cycle. Kõivomägi et al. demonstrate that multisite phosphorylations of Sic1 are not random events, but are part of a specific phosphorylation cascade catalysed by two different Cdk–cyclin complexes, with initial priming phosphorylations followed by docking-dependent phosphorylation events. Such an intricate mechanism may also apply to other kinase targets with multiple phosphorylation sites.

Suggested Citation

  • Mardo Kõivomägi & Ervin Valk & Rainis Venta & Anna Iofik & Martin Lepiku & Eva Rose M. Balog & Seth M. Rubin & David O. Morgan & Mart Loog, 2011. "Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase," Nature, Nature, vol. 480(7375), pages 128-131, December.
    • Handle: RePEc:nat:nature:v:480:y:2011:i:7375:d:10.1038_nature10560
    DOI: 10.1038/nature10560
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    Cited by:

    1. Alex N Nguyen Ba & Bob Strome & Jun Jie Hua & Jonathan Desmond & Isabelle Gagnon-Arsenault & Eric L Weiss & Christian R Landry & Alan M Moses, 2014. "Detecting Functional Divergence after Gene Duplication through Evolutionary Changes in Posttranslational Regulatory Sequences," PLOS Computational Biology, Public Library of Science, vol. 10(12), pages 1-15, December.

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