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A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

Author

Listed:
  • Hua Tian

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Brian Biehs

    (Institute for Human Genetics and Program in Craniofacial and Mesenchymal Biology, UCSF, 513 Parnassus Avenue, San Francisco, California 94143-0442, USA)

  • Søren Warming

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Kevin G. Leong

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Linda Rangell

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ophir D. Klein

    (Institute for Human Genetics and Program in Craniofacial and Mesenchymal Biology, UCSF, 513 Parnassus Avenue, San Francisco, California 94143-0442, USA)

  • Frederic J. de Sauvage

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

Stem cells held in reserve Two main epithelial stem-cell pools have been previously identified in the small intestine epithelium, but the relative functions of these two pools and their interrelationship are not well understood. Using genetic lineage tracing and lineage ablation studies in mice, Frederic de Sauvage and colleagues have now found that Lgr5-expressing cells are dispensable for normal intestinal homeostasis — the renewal of the epithelium every few days. In the absence of these cells, Bmi1-expressing cells act as a reserve stem-cell pool and replenish the active Lgr5-expressing stem cells.

Suggested Citation

  • Hua Tian & Brian Biehs & Søren Warming & Kevin G. Leong & Linda Rangell & Ophir D. Klein & Frederic J. de Sauvage, 2011. "A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable," Nature, Nature, vol. 478(7368), pages 255-259, October.
    • Handle: RePEc:nat:nature:v:478:y:2011:i:7368:d:10.1038_nature10408
    DOI: 10.1038/nature10408
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    Cited by:

    1. Tsunaki Higa & Yasutaka Okita & Akinobu Matsumoto & Shogo Nakayama & Takeru Oka & Osamu Sugahara & Daisuke Koga & Shoichiro Takeishi & Hirokazu Nakatsumi & Naoki Hosen & Sylvie Robine & Makoto M. Take, 2022. "Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Jina Yun & Simon Hansen & Otto Morris & David T. Madden & Clare Peters Libeu & Arjun J. Kumar & Cameron Wehrfritz & Aaron H. Nile & Yingnan Zhang & Lijuan Zhou & Yuxin Liang & Zora Modrusan & Michelle, 2023. "Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Adrian On Wah Leung & Andrew Chung Hin Poon & Xue Wang & Chen Feng & Peikai Chen & Zhengfan Zheng & Michael KaiTsun To & Wilson Cheuk Wing Chan & Martin Cheung & Danny Chan, 2024. "Suppression of apoptosis impairs phalangeal joint formation in the pathogenesis of brachydactyly type A1," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Anna Urciuolo & Giovanni Giuseppe Giobbe & Yixiao Dong & Federica Michielin & Luca Brandolino & Michael Magnussen & Onelia Gagliano & Giulia Selmin & Valentina Scattolini & Paolo Raffa & Paola Caccin , 2023. "Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Joana Silva & Ferhat Alkan & Sofia Ramalho & Goda Snieckute & Stefan Prekovic & Ana Krotenberg Garcia & Santiago Hernández-Pérez & Rob Kammen & Danielle Barnum & Liesbeth Hoekman & Maarten Altelaar & , 2022. "Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Jeremiah Bernier-Latmani & Cristina Mauri & Rachel Marcone & François Renevey & Stephan Durot & Liqun He & Michael Vanlandewijck & Catherine Maclachlan & Suzel Davanture & Nicola Zamboni & Graham W. K, 2022. "ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    7. Shamir Montazid & Sheila Bandyopadhyay & Daniel W. Hart & Nan Gao & Brian Johnson & Sri G. Thrumurthy & Dustin J. Penn & Bettina Wernisch & Mukesh Bansal & Philipp M. Altrock & Fabian Rost & Patrycja , 2023. "Adult stem cell activity in naked mole rats for long-term tissue maintenance," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    8. Yi Liu & Efren Reyes & David Castillo-Azofeifa & Ophir D. Klein & Todd Nystul & Diane L. Barber, 2023. "Intracellular pH dynamics regulates intestinal stem cell lineage specification," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    9. Adam E. Hall & Sebastian Öther-Gee Pohl & Patrizia Cammareri & Stuart Aitken & Nicholas T. Younger & Michela Raponi & Caroline V. Billard & Alfonso Bolado Carrancio & Aslihan Bastem & Paz Freile & Fio, 2022. "RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    10. Mara Martín-Alonso & Sharif Iqbal & Pia M. Vornewald & Håvard T. Lindholm & Mirjam J. Damen & Fernando Martínez & Sigrid Hoel & Alberto Díez-Sánchez & Maarten Altelaar & Pekka Katajisto & Alicia G. Ar, 2021. "Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

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