IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v475y2011i7357d10.1038_nature10307.html
   My bibliography  Save this article

Legionella pneumophila SidD is a deAMPylase that modifies Rab1

Author

Listed:
  • Yunhao Tan

    (Purdue University, 915 West State Street, West Lafayette, Indiana 47907, USA)

  • Zhao-Qing Luo

    (Purdue University, 915 West State Street, West Lafayette, Indiana 47907, USA)

Abstract

A pathogen's protein armoury Legionella pneumophila secretes multiple effectors into host cells during infection, some of which modify host trafficking and thereby aid intracellular replication. One of these modifications is AMPylation of Rab1 by L. pneumophila SidM. This study adds another layer to this regulation by demonstrating that a second L. pneumophila effector, SidD, deAMPylates Rab1. The identification of SidD suggests that this pathogen uses a specific set of proteins to hijack the activity of Rab1 for its own purposes.

Suggested Citation

  • Yunhao Tan & Zhao-Qing Luo, 2011. "Legionella pneumophila SidD is a deAMPylase that modifies Rab1," Nature, Nature, vol. 475(7357), pages 506-509, July.
  • Handle: RePEc:nat:nature:v:475:y:2011:i:7357:d:10.1038_nature10307
    DOI: 10.1038/nature10307
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10307
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature10307?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yizhi Yuan & Florian M. Stumpf & Lisa A. Schlor & Olivia P. Schmidt & Philip Saumer & Luisa B. Huber & Matthias Frese & Eva Höllmüller & Martin Scheffner & Florian Stengel & Kay Diederichs & Andreas M, 2023. "Chemoproteomic discovery of a human RNA ligase," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Marietta S. Kaspers & Vivian Pogenberg & Christian Pett & Stefan Ernst & Felix Ecker & Philipp Ochtrop & Michael Groll & Christian Hedberg & Aymelt Itzen, 2023. "Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Tobias Sahr & Pedro Escoll & Christophe Rusniok & Sheryl Bui & Gérard Pehau-Arnaudet & Gregory Lavieu & Carmen Buchrieser, 2022. "Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:475:y:2011:i:7357:d:10.1038_nature10307. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.