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Control of TH17 cells occurs in the small intestine

Author

Listed:
  • Enric Esplugues

    (Yale University School of Medicine
    German Rheumatism Research Center (DRFZ), A Leibniz Institute
    Cluster of Excellence NeuroCure, Charite-Universitätsmedizin Berlin)

  • Samuel Huber

    (Yale University School of Medicine
    I. Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf)

  • Nicola Gagliani

    (San Raffaele Diabetes Research Institute (HSR-DRI))

  • Anja E. Hauser

    (German Rheumatism Research Center (DRFZ), A Leibniz Institute)

  • Terrence Town

    (Cedars-Sinai Medical Center
    David Geffen School of Medicine, University of California)

  • Yisong Y. Wan

    (Lineberger Comprehensive Cancer Center, The University of North Carolina, School of Medicine)

  • William O’Connor

    (Yale University School of Medicine)

  • Anthony Rongvaux

    (Yale University School of Medicine)

  • Nico Van Rooijen

    (Faculty of Medicine, Vrije Universiteit)

  • Ann M. Haberman

    (Yale University School of Medicine)

  • Yoichiro Iwakura

    (Center for Experimental Medicine, Institute of Medical Science, University of Tokyo)

  • Vijay K. Kuchroo

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School)

  • Jay K. Kolls

    (LSU Health Sciences Center)

  • Jeffrey A. Bluestone

    (Diabetes Center at the University of California San Francisco)

  • Kevan C. Herold

    (Yale University School of Medicine)

  • Richard A. Flavell

    (Yale University School of Medicine
    Howard Hughes Medical Institute)

Abstract

Keeping TH17 cells under wraps Interleukin-17-producing T helper (TH17) cells serve an important role in the immune system, but are strongly implicated in the pathogenesis of numerous autoimmune diseases including rheumatoid arthritis and multiple sclerosis. How the immune system controls TH17 cells in vivo remains unclear. Using mice in which tolerance was induced by CD3-specific antibody, a model of sepsis and influenza A viral infection, Esplugues et al. demonstrate that TH17 cells are kept in check by redirecting the cells to the small intestine where they are eliminated or re-programmed to acquire immunosuppressive and regulatory properties. This work identifies the gastrointestinal tract as a site for control of TH17 cells.

Suggested Citation

  • Enric Esplugues & Samuel Huber & Nicola Gagliani & Anja E. Hauser & Terrence Town & Yisong Y. Wan & William O’Connor & Anthony Rongvaux & Nico Van Rooijen & Ann M. Haberman & Yoichiro Iwakura & Vijay , 2011. "Control of TH17 cells occurs in the small intestine," Nature, Nature, vol. 475(7357), pages 514-518, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7357:d:10.1038_nature10228
    DOI: 10.1038/nature10228
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    Cited by:

    1. Joachim Hanna & Flavio Beke & Louise M. O’Brien & Chrysa Kapeni & Hung-Chang Chen & Valentina Carbonaro & Alexander B. Kim & Kamal Kishore & Timon E. Adolph & Mikkel-Ole Skjoedt & Karsten Skjoedt & Ma, 2022. "Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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