IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v475y2011i7355d10.1038_nature10138.html
   My bibliography  Save this article

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Author

Listed:
  • Bin-Zhi Qian

    (Center for the Study of Reproductive Biology and Women’s Health, Albert Einstein College of Medicine)

  • Jiufeng Li

    (Center for the Study of Reproductive Biology and Women’s Health, Albert Einstein College of Medicine)

  • Hui Zhang

    (Center for the Study of Reproductive Biology and Women’s Health, Albert Einstein College of Medicine)

  • Takanori Kitamura

    (Center for the Study of Reproductive Biology and Women’s Health, Albert Einstein College of Medicine)

  • Jinghang Zhang

    (Flow Cytometry Core Facility, Albert Einstein College of Medicine)

  • Liam R. Campion

    (Ortho Biotech Oncology R&D, 145 King of Prussia Road)

  • Elizabeth A. Kaiser

    (Ortho Biotech Oncology R&D, 145 King of Prussia Road)

  • Linda A. Snyder

    (Ortho Biotech Oncology R&D, 145 King of Prussia Road)

  • Jeffrey W. Pollard

    (Center for the Study of Reproductive Biology and Women’s Health, Albert Einstein College of Medicine)

Abstract

Monocyte recruitment in metastasis Macrophages are abundant in tumours, where they promote tumorigenesis and metastasis. Jeffrey Pollard and colleagues now identify inflammatory monocytes as a precursor population for the macrophages that promote breast cancer metastasis to the lung or bone. These cells are recruited through the cytokine CCL2 and promote tumour-cell extravasation (by producing the signal protein VEGF) and the seeding of metastases. These findings can explain the poor prognosis for breast cancer patients with elevated expression of CCL2.

Suggested Citation

  • Bin-Zhi Qian & Jiufeng Li & Hui Zhang & Takanori Kitamura & Jinghang Zhang & Liam R. Campion & Elizabeth A. Kaiser & Linda A. Snyder & Jeffrey W. Pollard, 2011. "CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis," Nature, Nature, vol. 475(7355), pages 222-225, July.
    • Handle: RePEc:nat:nature:v:475:y:2011:i:7355:d:10.1038_nature10138
    DOI: 10.1038/nature10138
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10138
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature10138?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ariane F. Busso-Lopes & Leandro X. Neves & Guilherme A. Câmara & Daniela C. Granato & Marco Antônio M. Pretti & Henry Heberle & Fábio M. S. Patroni & Jamile Sá & Sami Yokoo & César Rivera & Romênia R., 2022. "Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer," Nature Communications, Nature, vol. 13(1), pages 1-24, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:475:y:2011:i:7355:d:10.1038_nature10138. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.