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Cells of origin in cancer

Author

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  • Jane E. Visvader

    (The Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

Abstract

Both solid tumours and leukaemias show considerable histological and functional heterogeneity. It is widely accepted that genetic lesions have a major role in determining tumour phenotype, but evidence is also accumulating that cancers of distinct subtypes within an organ may derive from different 'cells of origin'. These cells acquire the first genetic hit or hits that culminate in the initiation of cancer. The identification of these crucial target cell populations may allow earlier detection of malignancies and better prediction of tumour behaviour, and ultimately may lead to preventive therapies for individuals at high risk of developing cancer.

Suggested Citation

  • Jane E. Visvader, 2011. "Cells of origin in cancer," Nature, Nature, vol. 469(7330), pages 314-322, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7330:d:10.1038_nature09781
    DOI: 10.1038/nature09781
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    Cited by:

    1. Lu Han & Yongxia Wu & Kun Fang & Sean Sweeney & Ulyss K. Roesner & Melodie Parrish & Khushbu Patel & Tom Walter & Julia Piermattei & Anthony Trimboli & Julia Lefler & Cynthia D. Timmers & Xue-Zhong Yu, 2023. "The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Yuxuan Liu & Zhimin Gu & Hui Cao & Pranita Kaphle & Junhua Lyu & Yuannyu Zhang & Wenhuo Hu & Stephen S. Chung & Kathryn E. Dickerson & Jian Xu, 2021. "Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Sun Young Lee & Farhan Haq & Deokhoon Kim & Cui Jun & Hui-Jong Jo & Sung-Min Ahn & Won-Suk Lee, 2014. "Comparative Genomic Analysis of Primary and Synchronous Metastatic Colorectal Cancers," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-9, March.
    4. Veronica Veschi & Alice Turdo & Chiara Modica & Francesco Verona & Simone Franco & Miriam Gaggianesi & Elena Tirrò & Sebastiano Bella & Melania Lo Iacono & Vincenzo Davide Pantina & Gaetana Porcelli &, 2023. "Recapitulating thyroid cancer histotypes through engineering embryonic stem cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Yanying Wang & Jing Wang & Xiaoyu Li & Xushen Xiong & Jianyi Wang & Ziheng Zhou & Xiaoxiao Zhu & Yang Gu & Dan Dominissini & Lei He & Yong Tian & Chengqi Yi & Zusen Fan, 2021. "N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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